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Case Reports
. 2024 Jul 25;10(15):e35206.
doi: 10.1016/j.heliyon.2024.e35206. eCollection 2024 Aug 15.

Intermittent theta-burst stimulation in aphasia caused by right side cerebral lesions after stroke: A case report with 2-year follow-up

Haozheng Li  1   2 , Shunjuan Fan  1   2 , Yi Wu  1   2 , Dongxiang Fang  1   2 , Ruiping Hu  1   2 , Rongrong Lu  1   2
Affiliations
Case Reports

Intermittent theta-burst stimulation in aphasia caused by right side cerebral lesions after stroke: A case report with 2-year follow-up

Haozheng Li et al. Heliyon. .

Abstract

Background and objectives: This case report investigates the application of intermittent Theta-Burst Stimulation (iTBS) in aphasia rehabilitation following a right hemisphere stroke.

Case presentation: A 52-year-old Chinese male with Broca's aphasia post-stroke was treated with iTBS. His progress was evaluated using Functional Near-Infrared Spectroscopy (fNIRS) and behavioral assessments. Significant language function improvement was noted, with fNIRS showing increased activation in right hemisphere language-related cortical areas and altered functional connectivity patterns.

Conclusion: The findings indicate that iTBS is effective in facilitating language recovery in right hemisphere stroke-induced aphasia, highlighting the importance of personalized neurorehabilitation strategies. Despite focusing on a single case, the study contributes to understanding neural plasticity mechanisms in right hemisphere stroke-induced aphasia.

Keywords: Aphasia; Functional near-infrared spectroscopy; Intermittent theta-burst stimulation; Neural plasticity; Stroke.

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Conflict of interest statement

We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of the manuscript entitled.

Figures

Fig. 1
Fig. 1
MRI of the patient, the brain lesion was predominantly located in his right hemisphere.
Fig. 2
Fig. 2
(A) Sensitivity profile, sources are displayed with red dots while detectors are displayed with blue dots and channels with yellow lines. Results of the Monte-Carlo simulation based on 1 × 10-8 photons. (B) Scenarios for fNIRS scanning (C) Phrase repetition task. (D) Picture naming task.
Fig. 3
Fig. 3
Bright colours in the task-state images denote regions of increased brain activation (p < 0.05). In the resting-state images, functional connectivity was categorized into three areas: the left language-related cortex, the right language-related cortex, and the functional connectivity between the left and right cortices. These areas are outlined by a black box. Warm colours represent a higher strength of functional connectivity, while cool colours signify a lower strength of functional connectivity.
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