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. 2024 Oct 8;68(10):e0073424.
doi: 10.1128/aac.00734-24. Epub 2024 Aug 21.

Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation

Rachel Sintes  1   2   3   4 , Paul McLellan  2   3   4   5 , Gabriele Navelli  1   2   3   4 , Cécilia Landman  2   3   4   5 , Sandrine Delage  1   2   3   4 , Sandrine Truong  2   3   4   5 , Nicolas Benech  4   6 , Nathalie Kapel  2   3   4   7 , Alicia Moreino Sabater  2   3   4   8 , Aurélie Schnuriger  2   3   4   9 , Catherine Eckert  2   3   4   10 , Alexandre Bleibtreu  2   3   4   11 , Anne-Christine Joly  1   2   3   4 , Harry Sokol  2   3   4   5   12
Affiliations

Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation

Rachel Sintes et al. Antimicrob Agents Chemother. .

Abstract

Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.

Keywords: Clostridium difficile; FMT; fecal microbiota transplantation.

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Conflict of interest statement

H.S. reports lecture fee, board membership, or consultancy from Amgen, Fresenius, IPSEN, Actial, Astellas, Danone, THAC, Biose, BiomX, Eligo, Immusmol, Adare, Nestle, Ferring, MSD, Bledina, Pfizer, Biocodex, BMS, Bromatech, Gilead, Janssen, Mayoli, Roche, Sanofi, Servier, Takeda, Abbvie, and Lilly, has stocks from Enterome bioscience, and is co-founder of Exeliom Biosciences.

Figures

Fig 1
Fig 1
Clinical success of the two fecal preparation procedures. (A) Frozen fecal preparation (FFP), (B) fresh native frozen stool preparation (FNFP), (C) clinical success of FMT, and (D) clinical success of FMT restricted to donor D7.
See this image and copyright information in PMC

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