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. 2024 Aug;14(8):e1813.
doi: 10.1002/ctm2.1813.

The healing power of sensory neurons: New horizons for diabetic and neuropathic tissue repair

Yen-Zhen Lu  1 , Sanjay Ramakrishnan  2 , Mikaël M Martino  1   3   4
Affiliations

The healing power of sensory neurons: New horizons for diabetic and neuropathic tissue repair

Yen-Zhen Lu et al. Clin Transl Med. 2024 Aug.
No abstract available

Keywords: chronic wounds; diabetes; immune system; sensory neurons.

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Conflict of interest statement

Monash University has filed for patent protection on the molecular design described herein, and Yen‐Zhen Lu and Mikaël M. Martino are named as inventors. Sanjay Ramakrishna declares no conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Nociceptive sensory neuron endings grow into injured tissue following acute injury and release the neuropeptide calcitonin gene‐related peptide (CGRP). CGRP signalling in neutrophils and macrophages triggers the release of TSP‐1, which modulates these immune cells in an autocrine/paracrine manner to create a pro‐healing environment. (B) In the diabetic condition, there are fewer CGRP sensory neurons in tissues, and thus less CGRP is released at the site of injury, contributing to impaired tissue healing. (C) As a therapeutic approach, an engineered form of CGRP with improved pharmacokinetics is delivered into the injured tissue to accelerate the healing process.
See this image and copyright information in PMC

References

    1. Lu YZ, Nayer B, Singh SK, et al. CGRP sensory neurons promote tissue healing via neutrophils and macrophages. Nature. 2024;628(8008):604‐611. - PMC - PubMed
    1. Saraiva‐Santos T, Zaninelli TH, Pinho‐Ribeiro FA. Modulation of host immunity by sensory neurons. Trends Immunol. 2024;45(5):381‐396. - PubMed
    1. Wei JJ, Kim HS, Spencer CA, et al. Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration. Sci Immunol. 2020;5(50):eaba5683. - PMC - PubMed
    1. Hoeffel G, Debroas G, Roger A, et al. Sensory neuron‐derived TAFA4 promotes macrophage tissue repair functions. Nature. 2021;594(7861):94‐99. - PubMed
    1. Pittenger GL, Ray M, Burcus NI, McNulty P, Basta B, Vinik AI. Intraepidermal nerve fibers are indicators of small‐fiber neuropathy in both diabetic and nondiabetic patients. Diabetes Care. 2004;27(8):1974‐1979. - PubMed

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