Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Aug 21;148(1):26.
doi: 10.1007/s00401-024-02779-x.

FGFR1 wild-type rosette-forming glioneuronal tumours

Mégane Le Quang  1 , Aude Trinquet  2   3 , Aurore Siegfried  4   5 , Amaury de Barros  6 , Luc Bauchet  3   7 , Sam Ng  3   7 , Vincent Jecko  8 , Guillaume Chotard  1 , Morgan Ollivier  9 , Gilles Adam  10 , Fabrice Bonneville  10 , Julien Masliah-Planchon  11   12 , Yvan Nicaise  5 , Clémentine Decamps  5 , Valérie Rigau  2   3 , Emmanuelle Uro-Coste  13   14   15
Affiliations
Case Reports

FGFR1 wild-type rosette-forming glioneuronal tumours

Mégane Le Quang et al. Acta Neuropathol. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
MRI on the T1 sequence revealed well-circumscribed lesions with heterogeneous gadolinium enhancement located in the third ventricle obstructing the two interventricular foramens and invading the basal cisterns in case 1 (a), in the fourth ventricle in case 2 (d) and in the right mesencephalon in case 3 (g). Haematoxylin and eosin (HE) staining showed characteristic neurocytic rosettes viewed longitudinally, with a columnar arrangement in this small biopsy in case 1 (b), a biphasic proliferation with neurocytic rosettes (left) and piloid features (right) in case 2 (e) and rosettes with various size and shapes in case 3 (h). Cell staining for synaptophysin was diffuse and strong in case 1 (c), more heterogeneous in cases 2 (f) and 3 (i). Zoom on t-SNE using idat files freely available on GEO (publication PMID: 29539639) enhanced with personal data on extraventricular neurocytomas (EVN) (j). Schematic representation of KIF5B-ERBB4 fusions in case 1 and in the lung adenocarcinoma described by Guenzi et al. [6] (top) compared to the KIF5B-NTRK2 fusion reported in extraventricular neurocytoma by Gubbiotti et al. [5] (bottom) (k)
See this image and copyright information in PMC

References

    1. Appay R, Bielle F, Sievers P, Barets D, Fina F, Boutonnat J et al (2022) Rosette-forming glioneuronal tumours are midline, FGFR1-mutated tumours. Neuropathol Appl Neurobiol 48(5):e12813. 10.1111/nan.12813 10.1111/nan.12813 - DOI - PubMed
    1. Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM et al (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448(7152):439–344. 10.1038/nature05933 10.1038/nature05933 - DOI - PubMed
    1. Davies BR, Guan N, Logie A, Crafter C, Hanson L, Jacobs V et al (2015) Tumors with AKT1E17K mutations are rational targets for single agent or combination therapy with AKT inhibitors. Mol Cancer Ther 14(11):2441–2451. 10.1158/1535-7163.MCT-15-0230 10.1158/1535-7163.MCT-15-0230 - DOI - PubMed
    1. Gow CH, Liu YN, Li HY, Hsieh MS, Chang SH, Luo SC et al (2018) Oncogenic function of a KIF5B-MET fusion variant in non-small cell lung cancer. Neoplasia 20(8):838–847. 10.1016/j.neo.2018.06.007 10.1016/j.neo.2018.06.007 - DOI - PMC - PubMed
    1. Gubbiotti MA, Santi M, Storm PB, Li M, Xu F, Abdullaev Z et al (2023) First-time identification of a KIF5B-NTRK2 fusion in extraventricular neurocytoma. J Neuropathol Exp Neurol 82(3):272–275. 10.1093/jnen/nlad002 10.1093/jnen/nlad002 - DOI - PMC - PubMed

Substances

LinkOut - more resources