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Case Reports
. 2024 Aug 21;18(1):80.
doi: 10.1007/s12105-024-01671-0.

Palisading Adenocarcinoma

Melad N Dababneh  1 , Christopher C Griffith  1   2 , Kaitlyn Ooms  3
Affiliations
Case Reports

Palisading Adenocarcinoma

Melad N Dababneh et al. Head Neck Pathol. .

Abstract

Palisading adenocarcinoma is a morphologically distinct salivary gland neoplasm that has been recently described with predilection to the sublingual gland. We report our experience with this neoplasm to corroborate and enrich the literature and further clarify its phenotype.

Keywords: Palisading adenocarcinoma; Sublingual gland.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
At low power, the tumor is hypercellular, well-circumscribed and encapsulated
Fig. 2
Fig. 2
The tumor shows no evidence of invasion into surrounding parenchyma (a), and is comprised of two cell components, a predominant palisading component arranged frequently in pseudo-rosettes, and scattered ductal component with eosinophilic cytoplasm and lumens (arrows) (b). The predominant cells are polygonal, arranged in trabeculae and pseudo-rosette around hyalinized centers (c), while the ductal component is seen frequently in clusters with occasional mucous cells (inset) (d)
Fig. 3
Fig. 3
Cam5.2 is strong in ducts and variably positive in the predominant cells (a), CK5/6 is strongly positive only in ducts (b), P63 is positive in a periductal pattern (c), and CD56 is diffusely and strongly positive only in the polygonal cells, while negative-to-equivocal in the ducts (arrow) (d)
See this image and copyright information in PMC

References

    1. Bishop JA, Weinreb I, van Vliet C et al (2023) Palisading adenocarcinoma: a morphologically unique salivary gland tumor with a neuroendocrine-like appearance and a predilection for the Sublingual glands of women. Am J Surg Pathol 47(10):1176–1185. 10.1097/PAS.0000000000002091 - PubMed
    1. Manini C, Provenza C, Suriani A, Montemagno A, Vergano R, López JI (2024) Palisading adenocarcinoma. Case report on a newly recognized tumor in the salivary glands. Pathol Res Pract 253:155088. 10.1016/j.prp.2023.155088 - PubMed

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