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Editorial
. 2024 Oct 1;35(10):1297-1299.
doi: 10.1681/ASN.0000000000000474. Epub 2024 Aug 21.

mRNA Modification and Mechanisms of Kidney Fibrosis

Midori Sakashita  1 , Reiko Inagi
Affiliations
Editorial

mRNA Modification and Mechanisms of Kidney Fibrosis

Midori Sakashita et al. J Am Soc Nephrol. .
No abstract available

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Conflict of interest statement

Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/JSN/E803.

References

    1. Wang JN Wang F Ke J, et al. Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms. Sci Transl Med. 2022;14(640):eabk2709. doi: 10.1126/scitranslmed.abk2709 - DOI - PubMed
    1. Tsai YC Hsieh TH Liao YR, et al. METTL3-mediated N6-methyladenosine mRNA modification and cGAS-STING pathway activity in kidney fibrosis. J Am Soc Nephrol. 2024;35(10):1312–1329. doi: 10.1681/ASN.0000000000000428 - DOI - PMC - PubMed
    1. Maekawa H Inoue T Ouchi H, et al. Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury. Cell Rep. 2019;29(5):1261–1273.e6. doi: 10.1016/j.celrep.2019.09.050 - DOI - PubMed
    1. Chung KW Dhillon P Huang S, et al. Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell Metab. 2019;30(4):784–799.e5. doi: 10.1016/j.cmet.2019.08.003 - DOI - PMC - PubMed
    1. Skopelja-Gardner S, An J, Elkon KB. Role of the cGAS-STING pathway in systemic and organ-specific diseases. Nat Rev Nephrol. 2022;18(9):558–572. doi: 10.1038/s41581-022-00589-6 - DOI - PMC - PubMed

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