Response by Goonewardena et al to Letter Regarding Article, "Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19"

Affiliations

¹ Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (S.N.G., A.M.T., O.G.G., D.D.P.V., P.B., S.S.H., D.J.P.).
² Metabolism and Lipids Unit, Cardiovascular Institute, Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, NY (Q.C., R.S.R.).

Comment

Sascha N Goonewardena et al. Arterioscler Thromb Vasc Biol. 2024 Sep.

. 2024 Sep;44(9):e240-e241.

doi: 10.1161/ATVBAHA.124.321392. Epub 2024 Aug 21.

¹ Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (S.N.G., A.M.T., O.G.G., D.D.P.V., P.B., S.S.H., D.J.P.).
² Metabolism and Lipids Unit, Cardiovascular Institute, Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, NY (Q.C., R.S.R.).

No abstract available

Conflict of interest statement

None.

Letter by Brambilla et al Regarding Article, "Monocyte-Mediated Thrombosis Linked to Circulating Tissue-Factor and Immune Paralysis in COVID-19".
Brambilla M, Becchetti A, Nallio K, Camera M. Brambilla M, et al. Arterioscler Thromb Vasc Biol. 2024 Sep;44(9):e238-e239. doi: 10.1161/ATVBAHA.124.321299. Epub 2024 Aug 21. Arterioscler Thromb Vasc Biol. 2024. PMID: 39167674 No abstract available.

1. Goonewardena SN, Chen Q, Tate AM, Grushko OG, Damodaran D, Blakely P, et al. Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19. Arterioscler Thromb Vasc Biol 2024. doi: 10.1161/ATVBAHA.122.318721. - DOI - PMC - PubMed
1. Paludan SR, Mogensen TH. Innate immunological pathways in COVID-19 pathogenesis. Sci Immunol 2022;7:eabm5505. doi: 10.1126/sciimmunol.abm5505. - DOI - PubMed
1. Hottz ED, Martins-Gonçalves R, Palhinha L, Azevedo-Quintanilha IG, De Campos MM, Sacramento CQ, et al. Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19. Blood Advances 2022;6:5085–5099. doi: 10.1182/bloodadvances.2021006680. - DOI - PMC - PubMed
1. Flaumenhaft R, Enjyoji K, Schmaier AA. Vasculopathy in COVID-19. Blood 2022;140:222–235. doi: 10.1182/blood.2021012250. - DOI - PMC - PubMed
1. Skendros P, Mitsios A, Chrysanthopoulou A, Mastellos DC, Metallidis S, Rafailidis P, et al. Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis. Journal of Clinical Investigation 2020;130:6151–6157. doi: 10.1172/JCI141374. - DOI - PMC - PubMed