Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Aug 20;12(8):e9250.
doi: 10.1002/ccr3.9250. eCollection 2024 Aug.

A collision tumor of basal cell carcinoma and atypical fibroxanthoma: A case report

Mariko Suzuki-Ueno  1 , Yoshiaki Fujikawa  1 , Dai Hamaoka  1 , Kaoru Umemura  1 , Takamasa Ohnishi  2
Affiliations
Case Reports

A collision tumor of basal cell carcinoma and atypical fibroxanthoma: A case report

Mariko Suzuki-Ueno et al. Clin Case Rep. .

Abstract

An 83-year-old man presented an elevated skin lesion in the left temporal area. The resected specimen was identified between a basal cell carcinoma and an atypical fibroxanthoma. A final diagnosis of basal cell carcinoma and atypical fibroxanthoma was made. This study reports a rare case of a cutaneous collision.

Keywords: atypical fibroxanthoma; basal cell carcinoma; collision tumor; skin neoplasms.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Macroscopic images of the tumor. (A) Clinical photograph. A 30 × 25‐mm, elevated, erythematous skin mass is observed in the left temporal area. (B) Macroscopic image of the resected specimen. (C) The excised specimens are divided into seven sections. The mass is pale and yellowish white, with partially scattered white nodules and black spots reminiscent of bleeding. Multiple small cysts are observed just below the epidermis.
FIGURE 2
FIGURE 2
Histological findings of the tumor indicate components of both atypical fibroxanthoma and basal cell carcinoma. (A) Hematoxylin and eosin staining (HE) shows atypical basaloid cells protuberating from the epidermis into the dermis and subcutaneously in the form of cysts. Magnification: ×12.5. (B) HE reveals collision of BCC and AFX. Magnification: ×100. (C) HE shows cleft formation/palisading, typical of basal cell carcinoma. Magnification: ×400. (D) HE shows the proliferation of large monocytes, multinucleated giant cells, and oval‐to‐spindle‐shaped cells in the stroma. Magnification: ×400.
FIGURE 3
FIGURE 3
Immunohistochemical staining for basal cell carcinoma. Cells are positive for (A) cytokeratin (CK)5/6 and (B) p40, CK5/6, and p40. Findings from the immunohistochemical staining of the atypical fibroxanthoma. Cells are positive for (C) CD10 and (D) CD68.
See this image and copyright information in PMC

References

    1. Blum A, Siggs G, Marghoob AA, et al. Collision skin lesions‐results of a multicenter study of the international Dermoscopy society (IDS). Dermatol Pract Concept. 2017;7(4):51‐62. doi: 10.5826/dpc.0704a12 - DOI - PMC - PubMed
    1. Messina J, Epstein EH Jr, Kossard S, et al. Chapter 1. Keratinocytic/epidermal tumors. Basal cell carcinoma. In: Elder DE, Massi D, Scolyer RA, Willemze R, eds. WHO Classification of Skin Tumours. International Agency for Research on Cancer; 2017.
    1. Tamaki T, Dong Y, Ohno Y, Sobue T, Nishimoto H, Shibata A. The burden of rare cancer in Japan: application of the RARECARE definition. Cancer Epidemiol. 2014;38(5):490‐495. doi: 10.1016/j.canep.2014.07.014 - DOI - PubMed
    1. Lund HZ, Kraus JM. Melanotic Tumors of the Skin. Atypical Fibroxanthoma; Comparison with Malignant Melanoma; 1962.
    1. Anderson HL, Joseph AK. A pilot feasibility study of a rare skin tumor database. Dermatologic Surg. 2007;33(6):693‐696. doi: 10.1111/j.1524-4725.2007.33145.x - DOI - PubMed

Publication types

LinkOut - more resources