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. 2024 Aug 1;7(8):e2428953.
doi: 10.1001/jamanetworkopen.2024.28953.

Thiazide Dose, Urine Calcium, and Symptomatic Kidney Stone Events

Ryan S Hsi  1 , Phyllis L Yan  2 , Naim M Maalouf  3   4 , Sara L Best  5   6 , John R Asplin  6 , Vahakn Shahinian  2   7 , John M Hollingsworth  8
Affiliations

Thiazide Dose, Urine Calcium, and Symptomatic Kidney Stone Events

Ryan S Hsi et al. JAMA Netw Open. .
No abstract available

Plain language summary

This cohort study examines the association between thiazide dose and urine calcium reduction and correlates urine calcium changes with the occurrence of symptomatic kidney stone events.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure 1.
Figure 1.. Adjusted Mean Absolute and Percentage Change in Urine Calcium by Daily Thiazide Dose
Doses are classified as low (<12.5 mg/d chlorthalidone, <0.6125 mg/d indapamide, <25 mg/d hydrochlorothiazide), medium (12.5 to <25 mg/d chlorthalidone, 0.6125 to <1.25 mg/d indapamide, 25 to <50 mg/d hydrochlorothiazide), and high (≥25 mg/d chlorthalidone, ≥1.25 mg/d indapamide, ≥50 mg/d hydrochlorothiazide). Error bars indicate 95% CIs.
Figure 2.
Figure 2.. Kaplan-Meier Curves of Cumulative Incidence of a Symptomatic Stone Event at 4 Years of Follow-Up Across Individuals by Terciles
With low or minimal (mean [SD], 24 [61] mg/d), intermediate (mean [SD], −90 [25] mg/d), and high (mean [SD], −216 [74] mg/d) reductions in urine calcium.
See this image and copyright information in PMC

Comment in

References

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