Probing the relevance of BRCA1 and BRCA2 germline pathogenic variants beyond breast and ovarian cancer

William D Foulkes^{1

2

3}, Paz Polak⁴

Affiliations

¹ Department of Human Genetics, McGill University, Montreal, QC, Canada.
² Division of Medical Genetics, Department of Specialised Medicine, McGill University Health Centre, Montreal, QC, Canada.
³ Cancer Axis, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
⁴ Quest Diagnostics, Secaucus, NJ, USA.

Comment

William D Foulkes et al. J Natl Cancer Inst. 2024.

. 2024 Dec 1;116(12):1871-1874.

doi: 10.1093/jnci/djae184.

William D Foulkes^{1

2

3}, Paz Polak⁴

¹ Department of Human Genetics, McGill University, Montreal, QC, Canada.
² Division of Medical Genetics, Department of Specialised Medicine, McGill University Health Centre, Montreal, QC, Canada.
³ Cancer Axis, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
⁴ Quest Diagnostics, Secaucus, NJ, USA.

No abstract available

Comment on

Genomic instability in non-breast or ovarian malignancies of individuals with germline pathogenic variants in BRCA1/2.
Elze L, van der Post RS, Vos JR, Mensenkamp AR, Pamidimarri Naga S, Hampstead JE, Vermeulen E, Oorsprong M, Hofste T, Simons M, Nagtegaal ID, Hoogerbrugge N, de Voer RM, Ligtenberg MJL. Elze L, et al. J Natl Cancer Inst. 2024 Dec 1;116(12):1904-1913. doi: 10.1093/jnci/djae160. J Natl Cancer Inst. 2024. PMID: 38960732 Free PMC article.