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Comment
. 2024 Aug 23;385(6711):826-827.
doi: 10.1126/science.adr5836. Epub 2024 Aug 22.

Alzheimer's and metabolism wed with IDO1

Lance A Johnson  1   2 , Shannon L Macauley  1   2   3
Affiliations
Comment

Alzheimer's and metabolism wed with IDO1

Lance A Johnson et al. Science. .

Abstract

Kynurenine pathway inhibition reverses deficits in Alzheimer's mouse models.

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Figures

None
A metabolic target for Alzheimer’s
Amyloid-β peptide and tau protein activate the kynurenine (KYN) pathway by increasing indoleamine-2,3-dioxygenase 1 (IDO1), the enzyme that metabolizes tryptophan (TRP) to KYN, which impairs astrocyte metabolism, lactate flux, and neuronal function. Blocking IDO1 with PF068 or through genetic deletion restores metabolic flux, neuronal function, and cognition, demonstrating that glial metabolism is a potential therapeutic target in Alzheimer’s disease. ATP, adenosine 5′-triphosphate
See this image and copyright information in PMC

Comment on

  • Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
    Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. Minhas PS, et al. Science. 2024 Aug 23;385(6711):eabm6131. doi: 10.1126/science.abm6131. Epub 2024 Aug 23. Science. 2024. PMID: 39172838 Free PMC article.

References

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