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. 2024 Aug 22;19(8):e0306576.
doi: 10.1371/journal.pone.0306576. eCollection 2024.

Exploring the role of non-coding RNAs in atrial septal defect pathogenesis: A systematic review

Zahra AmiRsardari  1   2   3 , Akram Gholipour  1 , Zahra Khajali  1   3 , Majid Maleki  1 , Mahshid Malakootian  1
Affiliations

Exploring the role of non-coding RNAs in atrial septal defect pathogenesis: A systematic review

Zahra AmiRsardari et al. PLoS One. .

Abstract

Background: Extensive research has recognized the significant roles of non-coding RNAs (ncRNAs) in various cellular pathophysiological processes and their association with diverse diseases, including atrial septal defect (ASD), one of the most prevalent congenital heart diseases. This systematic review aims to explore the intricate involvement and significance of ncRNAs in the pathogenesis and progression of ASD.

Methods: Four databases (PubMed, Embase, Scopus, and the Web of Science) were searched systematically up to June 19, 2023, with no year restriction. The risk of bias assessment was evaluated using the Newcastle-Ottawa scale.

Results: The present systematic review included thirteen studies with a collective study population of 874 individuals diagnosed with ASD, 21 parents of ASD patients, and 22 pregnant women carrying ASD fetuses. Our analysis revealed evidence linking five long ncRNAs (STX18-AS1, HOTAIR, AA709223, BX478947, and Moshe) and several microRNAs (hsa-miR-19a, hsa-miR-19b, hsa-miR-375, hsa-miR-29c, miR-29, miR-143/145, miR-17-92, miR-106b-25, and miR-503/424, miR-9, miR-30a, miR-196a2, miR-139-5p, hsa-let-7a, hsa-let-7b, and hsa-miR-486) to ASD progression, corresponding to previous studies.

Conclusions: NcRNAs play a crucial role in unraveling the underlying mechanisms of ASD, contributing to both biomarker discovery and therapeutic advancements. This systematic review sheds light on the mechanisms of action of key ncRNAs involved in ASD progression, providing valuable insights for future research in this field.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. PRISMA flowchart of study selection and screening.
Fig 2
Fig 2. Differential expression of lncRNAs and miRNAs in ASD pathogenesis.
lncRNAs: long non-coding RNAs; miRNAs: microRNAs; ASD: atrial septal defect.
See this image and copyright information in PMC

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