Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jul-Aug;15(4):100957.
doi: 10.1016/j.jaim.2024.100957. Epub 2024 Aug 21.

Effectivity of oral ginger supplementation for chemotherapy induced nausea and vomiting (CINV) in children: A systematic review of clinical trials

Harri Hardi  1 , Geraldine Kenyo Estuworo  1 , Melva Louisa  2
Affiliations
Review

Effectivity of oral ginger supplementation for chemotherapy induced nausea and vomiting (CINV) in children: A systematic review of clinical trials

Harri Hardi et al. J Ayurveda Integr Med. 2024 Jul-Aug.

Abstract

Chemotherapy-induced nausea and vomiting (CINV) affects over 50% of pediatric patients undergoing chemotherapy, a higher proportion than in adults. CINV often occurs despite adequate antiemetic prophylaxis, hampering patients' willingness to continue the chemotherapy regimen. As an ayurvedic medicine, ginger (Zingiber officinale) has an antiemetic effect by inhibiting serotonin in gastrointestinal nerves and as an NK1 antagonist. Therefore, we aimed to review oral ginger supplementation in children with CINV systematically. Systematic searching was performed in June 2023 from Pubmed, Embase, CINAHL, Cochrane, and hand searching. The search consisted of PICO "children chemotherapy", "ginger", and "CINV incidence". We limited the search to only human studies. Studies that meet inclusion and exclusion criteria were included for analysis. Out of 116 studies found with our selection criteria, four were compatible with inclusion and exclusion criteria. Two studies had a small Risk of Bias (RoB), while the others had a high RoB. All studies statistically significantly reduced acute and delayed CINV with the number needed to treat (NNT) 2-4. No adverse effects were reported. However, these studies still had high heterogeneity based on cancer treatment, chemotherapy regimen, ginger dosing, and ginger processing. Ginger has the potential to reduce both the acute and delayed phases of CINV in children. Additional research employing standardized methodologies is recommended to validate this effect.

Keywords: Antiemesis; CINV; Chemotherapy; Pediatric; Zingiber officinale.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
PRISMA flow chart search strategy.
Fig. 2
Fig. 2
Risk of bias based on Cochrane risk-of-bias tool for randomized trials.
See this image and copyright information in PMC

References

    1. Johnston W.T., Erdmann F., Newton R., Steliarova-Foucher E., Schüz J., Roman E. Childhood cancer: Estimating regional and global incidence. Cancer Epidemiol. 2021;71 doi: 10.1016/j.canep.2019.101662. - DOI - PubMed
    1. Steliarova-Foucher E., Colombet M., Ries L.A.G., Moreno F., Dolya A., Bray F., et al. International incidence of childhood cancer, 2001-10: a population-based registry study. Lancet Oncol. 2017;18:719–731. doi: 10.1016/S1470-2045(17)30186-9. - DOI - PMC - PubMed
    1. Bakula D.M., Sharkey C.M., Perez M.N., Espeleta H.C., Gamwell K.L., Baudino M., et al. The relationship between parent distress and child quality of life in pediatric cancer: a meta-analysis. J Pediatr Nurs. 2020;50:14–19. doi: 10.1016/j.pedn.2019.09.024. - DOI - PubMed
    1. Chae W., Kim J., Park S., Park E.-C., Jang S.-I. The financial burden associated with medical costs among childhood cancer patients and their families related to their socioeconomic status: the perspective of national health insurance service. Int J Environ Res Publ Health. 2020;17:6020. doi: 10.3390/ijerph17176020. - DOI - PMC - PubMed
    1. Gupta K., Walton R., Kataria S.P. Chemotherapy-induced nausea and vomiting: pathogenesis, recommendations, and new trends. Cancer Treat Res Commun. 2021;26 doi: 10.1016/j.ctarc.2020.100278. - DOI - PubMed