Mortality Rate and Cause of Death in Adults with Extrapulmonary Nontuberculous Mycobacteria Infection, Denmark

Abstract

Evidence on mortality rates and causes of death associated with extrapulmonary nontuberculous mycobacteria (NTM) infection is limited. This nationwide register-based study in Denmark used diagnostic codes to match adult patients with extrapulmonary NTM infection 1:4 to controls. During 2000–2017, we identified 485 patients, who had significantly more comorbidities than controls. The 5-year mortality rate for patients was 26.8% (95% CI 23.1%–31.0%) and for controls, 10.9% (95% CI 9.6%–12.4%). The median age at death was 76 (interquartile range 63–85) years for patients and 84 (interquartile range 73–90) years for controls. The adjusted hazard rate of death for patients was 1.34 (95% CI 1.10–1.63; p = 0.004). Patients and controls mainly died of cardiovascular disease and solid malignant neoplasms. Hematologic malignancies and HIV were more frequently causes of death in patients. Mortality rates are substantial among patients with extrapulmonary NTM infection, predominantly caused by underlying conditions.

Keywords: Denmark; causes of death; epidemiology; extrapulmonary nontuberculous mycobacterial disease; mortality; mycobacteria; nontuberculous mycobacterial disease; tuberculosis and other mycobacteria.

Figure

Cumulative mortality rate for patients with extrapulmonary NTM infection compared with matched controls in study of mortality and cause of death in adults with extrapulmonary NTM infection, Denmark. log-rank p<0.001. NTM, nontuberculous mycobacteria.