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Case Reports
. 2024 Oct;9(5):1997-1999.
doi: 10.1002/epi4.12948. Epub 2024 Aug 22.

Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome

Nicola Pietrafusa  1 , Luca De Palma  1 , Michelina Armando  2 , Tiziana Corsetti  3 , Federico Vigevano  4 , Nicola Specchio  1
Affiliations
Case Reports

Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome

Nicola Pietrafusa et al. Epilepsia Open. 2024 Oct.
No abstract available

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Conflict of interest statement

PN has received speaker fees or fundings or has participated in advisory boards for Angelini and UCB. DPL, AM, CT report no conflict of interest. VF has received speaker fees or fundings or has participated in advisory boards for Zogenix, Neuraxpharm, Angelini, Eisai, and Neuraxpharm. SN has served on scientific advisory boards for GW Pharma, BioMarin, Arvelle, Marinus, and Takeda; has received speaker honoraria from Eisai, Biomarin, Livanova, Sanofi; has served as an investigator for Zogenix, Marinus, Biomarin, UCB, Roche.

Figures

FIGURE 1
FIGURE 1
EEG during the drowsiness and frequent seizures. This patient was recorded few days after the symptoms began. Continuous high amplitude, diffuse, irregular spike–wave complexes with higher amplitude over bilateral frontal regions, in sequences with a rhythmic‐recruiting pattern (A). Oromucosal midazolam was administered without significant changes (B). After 1 day EEG still showed continuous spike and waves discharges, EMG channels show multiple asynchronous and asymmetric myoclonic jerks over bilateral deltoids, and neck muscles. The patient was also presenting head drops typically seen in NCSE (minor motor status). Both valproate (C) and levetiracetam (D) were ineffective. He started Epydiolex CBD and after 2 days (E) and 7 days (F) there was a marked reduction of EEG epileptiform abnormalities and a resolution of NCSE. After 15 days (G) still some repetitive spikes were evident over asynchronous bilateral temporal and parietal regions. After 29 days (H), there was an improvement of background activity, further reduction in epileptiform abnormalities and the patient was persistently free from seizures.
See this image and copyright information in PMC

References

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