Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jul 22;16(7):e65149.
doi: 10.7759/cureus.65149. eCollection 2024 Jul.

Poorly Differentiated Thyroid Carcinoma in a 19-Year-Old Young Female Patient: A Case Report

Atul Chavhan  1 , Anjali A Vagga  2 , Prachi Gedekar  3 , Amit Bhoyar  1 , Garima S Agarwal  1
Affiliations
Case Reports

Poorly Differentiated Thyroid Carcinoma in a 19-Year-Old Young Female Patient: A Case Report

Atul Chavhan et al. Cureus. .

Abstract

Poorly differentiated thyroid carcinoma (PDTC) is a rare type of thyroid carcinoma that develops from follicular epithelial cells. In terms of morphology and prognosis, PDTC falls between well-differentiated thyroid carcinoma (WDTC) and anaplastic thyroid carcinoma (ATC). The spectrum of malignant thyroid tumors originating from follicles ranges from the fatal ATC at one end to the indolent WDTC at the other. We present a case of a 19-year-old female patient complaining of swelling on the right side of the neck. Computed tomography revealed a solid cystic lesion within the right lobe of the thyroid gland. The diagnosis of PDTC was made through histopathological examination. In this case, we evaluated the histological characteristics of the right lobe of the thyroid gland and presented a case report of PDTC in a young female.

Keywords: carcinoma; computed tomography; histopathology; poorly differentiated thyroid carcinoma; surgery.

PubMed Disclaimer

Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Computed tomography shows a solid cystic lesion within the right lobe of the thyroid.
Figure 2
Figure 2. Gross specimen of the right lobe section of the thyroid gland.
Figure 3
Figure 3. Microscopy shows normal thyroid follicles with colloids.
Figure 4
Figure 4. Section shows extensive areas of tumor necrosis with tumor cells arranged in trabeculae separated by vesicular septa. Pleomorphic nuclei are also seen with vesicular chromatin binucleation.
See this image and copyright information in PMC

References

    1. Update on fundamental mechanisms of thyroid cancer. Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M. Front Endocrinol (Lausanne) 2020;11:102. - PMC - PubMed
    1. Updates on the management of thyroid cancer. Araque KA, Gubbi S, Klubo-Gwiezdzinska J. Horm Metab Res. 2020;52:562–577. - PMC - PubMed
    1. Poorly differentiated carcinoma of the thyroid gland: current status and future prospects. Ibrahimpasic T, Ghossein R, Shah JP, Ganly I. Thyroid. 2019;29:311–321. - PMC - PubMed
    1. Poorly differentiated and anaplastic thyroid cancer: insights into genomics, microenvironment and new drugs. Prete A, Matrone A, Gambale C, et al. Cancers (Basel) 2021;13 - PMC - PubMed
    1. Poorly differentiated thyroid carcinoma: an underdiagnosed entity. Dettmer MS, Schmitt A, Komminoth P, Perren A. Pathologe. 2020;41:1–8. - PMC - PubMed

Publication types

LinkOut - more resources