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. 2024 Sep 20;26(37):7817-7821.
doi: 10.1021/acs.orglett.4c02560. Epub 2024 Aug 23.

Synthetic Nicotinamide Cofactors as Alternatives to NADPH in Imine Reductase-Catalyzed Reactions

Wei Kang  1   2   3 , Shushan Gao  3   4 , Jinping Bao  3 , Lujia Yang  3 , Yaqing Ma  3 , Pingyuan Wang  1   2 , Chang-Yun Wang  1   2 , Chengsen Cui  3   4
Affiliations

Synthetic Nicotinamide Cofactors as Alternatives to NADPH in Imine Reductase-Catalyzed Reactions

Wei Kang et al. Org Lett. .

Erratum in

Abstract

This study demonstrates the effectiveness of synthetic nicotinamide cofactors as cost-effective alternatives to NADPH in imine reductase (IRED) catalysis. The synthetic cofactors maintained catalytic activity and stereoselectivity, achieving high conversion rates. Molecular docking studies revealed key structural interactions influencing performance. Combining a glucose dehydrogenase (GDH) recycling system further enhanced the stability and efficiency. These findings highlight the potential of synthetic cofactors to reduce costs and improve the feasibility of IRED-catalyzed processes for industrial applications.

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