An intrinsically disordered region in MED13 turns Mediator on/off on cue
- PMID: 39178836
- DOI: 10.1016/j.molcel.2024.07.027
An intrinsically disordered region in MED13 turns Mediator on/off on cue
Abstract
Complementary studies by Zhao et al.1 and Chen et al.2 reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching Mediator and transcription activation on and off.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
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