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. 2024 Aug 22;84(16):3005-3007.
doi: 10.1016/j.molcel.2024.07.027.

An intrinsically disordered region in MED13 turns Mediator on/off on cue

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Free article

An intrinsically disordered region in MED13 turns Mediator on/off on cue

Vincent Villeret et al. Mol Cell. .
Free article

Abstract

Complementary studies by Zhao et al.1 and Chen et al.2 reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching Mediator and transcription activation on and off.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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