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. 1985 Feb;87(2):377-81.
doi: 10.1016/0014-4886(85)90228-6.

Efficacy of phenytoin, procainamide, and tocainide in murine genetic myotonia

R Aichele, H Paik, A H Heller

Efficacy of phenytoin, procainamide, and tocainide in murine genetic myotonia

R Aichele et al. Exp Neurol. 1985 Feb.

Abstract

A newly described single locus mutation in the mouse, myotonia (mto), features classical myotonia with autosomal recessive inheritance. Phenytoin, procainamide, and tocainide (drugs considered effective in the human myotonias) produced dose-dependent improvement in the behavioral myotonia of mto homozygotes.

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