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Meta-Analysis
. 2025 Jan;263(1):147-156.
doi: 10.1007/s00417-024-06592-w. Epub 2024 Aug 23.

Association between vitamin D level and cataract: A systematic review and meta-analysis

Zhenzhen Jue  1 , Ziming Xu  1 , Vincent L Yuen  1 , Odessa Dik San Chan  1 , Jason C Yam  2   3   4   5
Affiliations
Meta-Analysis

Association between vitamin D level and cataract: A systematic review and meta-analysis

Zhenzhen Jue et al. Graefes Arch Clin Exp Ophthalmol. 2025 Jan.

Abstract

Purpose: The association between serum vitamin D level and cataract remains controversial. This study aims to evaluate the association between vitamin D level and cataract.

Methods: In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 30 August 2023 and 626 articles were screened. Four studies involving a total of 10,928 subjects with cataract and 10,117 control subjects met the inclusion criteria.

Results: Decreased serum vitamin D level was associated with higher incidence of cataract (P = 0.047; MD: -4.87; 95%CI: [-9.67, -0.07]). In the subgroup analysis by sex, a significant association was found between serum vitamin D level and cataract in both male (P = 0.01, MD: -2.15,95%CI: [-3.83, -0.46]) and female (P < 0.01; MD: -6.67,95%CI: [-8.20, -5.14]).In the subgroup analysis by the types of cataract, significant association was found between serum vitamin D level and nuclear (P < 0.01; MD: -10.48; 95%CI: [-12.72, -8.24]) and posterior subcapsular cataract (P = 0.02; MD: -6.05; 95%CI: [-11.30, -0.80]) but not in cortical cataract (P = 0.14; MD: -6.74; 95%CI: [-15.70, 2.22]).

Conclusion: This meta-analysis revealed potential association between serum vitamin D level and cataract, more significant in female, and the subtypes of nuclear and posterior subcapsular cataract.

Keywords: Cataract; Serum vitamin D level; Types of cataract; Vitamin D.

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Conflict of interest statement

Declarations. Ethical approval: Regarding this systematic review and meta-analysis, no approval was required from an authorized Medical Ethics Committee since this is a review of priorly published studies with no patient identifying information. Informed consent: All authors also ascertain that informed consent was confirmed to had been obtained from all individual participants involved in the included studies. Conflict of Interest: All authors declare no conflict of interests.

Figures

Fig. 1
Fig. 1
PRISMA Flow Diagram
Fig. 2
Fig. 2
Forest plot of the mean differences in the serum 25(OH)D level between cataract and control groups
Fig. 3
Fig. 3
Forest plot of subgroup analysis of the associations between serum 25(OH)D level and cataract in different gender groups
Fig. 4
Fig. 4
Forest plot of subgroup analysis of the association between serum 25(OH)D level and different types of cataract
Fig. 5
Fig. 5
Risk of bias of all included studies
Fig. 6
Fig. 6
Forest plot of sensitivity analysis
See this image and copyright information in PMC

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References

    1. Liu YC, Wilkins M, Kim T, Malyugin B, Mehta JS (2017) Cataracts. Lancet (London, England) 390(10094):600–612. 10.1016/s0140-6736(17)30544-5 - PubMed
    1. Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S (2005) Age-related cataract. Lancet (London, England). 365(9459):599–609. 10.1016/s0140-6736(05)17911-2 - PubMed
    1. Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR (2017) Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Global Health 5(12):e1221–e1234. 10.1016/s2214-109x(17)30393-5 - PubMed
    1. Choquet H, Melles RB, Anand D, Yin J, Cuellar-Partida G, Wang W, Hoffmann TJ, Nair KS, Hysi PG, Lachke SA, Jorgenson E (2021) A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Nature Commun 12(1):3595. 10.1038/s41467-021-23873-8 - PMC - PubMed
    1. Wang Y, Li F, Zhang G, Kang L, Guan H (2016) Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation. Clinical Epigenetics 8:62. 10.1186/s13148-016-0229-y - PMC - PubMed

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