Synthesis of Diverse Ureas from Amines and CO2 at Atmospheric Pressure and Room Temperature

Abstract

A metal-free method is developed to perform the synthesis of urea derivatives utilizing CO₂ as the C1 building block at atmospheric pressure and room temperature. In addition to diverse symmetric and dissymmetric ureas, benzimidazolones and quinazolinone can also be easily prepared using this protocol. Most importantly, the gram-scale preparation of fungicide pencycuron and antipsychotic drug pimavanserin proceeded smoothly under the mild conditions.