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Review
. 2024 Dec;27(6):847-859.
doi: 10.1007/s11102-024-01439-3. Epub 2024 Aug 24.

Vitamin D in pituitary driven osteopathies

Sabrina Chiloiro  1   2 , Flavia Costanza  3   4 , Elena Riccardi  3   4 , Antonella Giampietro  3   4 , Laura De Marinis  3   4 , Antonio Bianchi  3   4 , Alfredo Pontecorvi  3   4 , Andrea Giustina  5
Affiliations
Review

Vitamin D in pituitary driven osteopathies

Sabrina Chiloiro et al. Pituitary. 2024 Dec.

Abstract

The evidence that pituitary hormones may bypass peripheral endocrine glands to exert remarkable effects on the skeleton is gaining ground. Both hormonal excess and deficit may determine impairment in bone structure, and they commonly result in bone loss in patients affected by pituitary and neuroendocrine disorders. Vertebral fractures are the most common skeletal alterations and may occur independently of bone mass. Use of vitamin D (VD) supplementation is still debated in this setting. This review will focus on the interactions between different metabolites of VD and pituitary hormones, and the effects of VD supplementation on bone metabolism in patients with pituitary diseases.

Keywords: Bone health; Fractures; Neuroendocrine diseases; Osteopenia; Osteoporosis; Pituitary diseases; Skeletal fragility; Vitamin D.

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Conflict of interest statement

Declarations. COI: SC recipient of Research grant to Institution from Ipsen, Pfizer and Recordati. AG consultant for Abiogen, Ipsen, Recordati and recipient of Research grant to Institution from Pfizer and Takeda.

Figures

Fig. 1
Fig. 1
Schematic representation of the effects of pituitary hormone hypersecretion and deficit on calcium, D vitamin D metabolism.
Fig. 2
Fig. 2
Schematic representation of the effects of pituitary hormone hypersecretion and deficit on bone metabolism and skeletal fragility.
See this image and copyright information in PMC

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