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. 2025 Feb;36(2):99-101.
doi: 10.1016/j.tem.2024.08.003. Epub 2024 Aug 23.

New anti-inflammatory mechanism of glucocorticoids uncovered

Carolyn L Cummins  1 , Ido Goldstein  2
Affiliations

New anti-inflammatory mechanism of glucocorticoids uncovered

Carolyn L Cummins et al. Trends Endocrinol Metab. 2025 Feb.

Abstract

Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

Keywords: GR; LPS; PDH; itaconate; macrophage.

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Conflict of interest statement

Declaration of interests None declared by authors.

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