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. 1985 Feb 18;36(7):671-7.
doi: 10.1016/0024-3205(85)90172-9.

Central dopaminergic activity influences rats ability to exercise

M P Heyes, E S Garnett, G Coates

Central dopaminergic activity influences rats ability to exercise

M P Heyes et al. Life Sci. .

Abstract

Rats were run to exhaustion on a motor driven treadmill. Apomorphine given to intact rats prolonged the time to exhaustion. Apomorphine given to 6-hydroxydopamine lesioned rats also prolonged the time to exhaustion. Intracerebroventricular 6-hydroxydopamine alone reduced the time to exhaustion. Clonidine given to these animals had no effect. We suggest that central dopaminergic activity influences rats ability to exercise.

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