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Review
. 2024 Oct:262:155535.
doi: 10.1016/j.prp.2024.155535. Epub 2024 Aug 13.

Update on the genetic profile of mitral valve development and prolapse

Carmen Elena Opris  1 , Horatiu Suciu  2 , Sanziana Flamand  3 , Cosmin Ioan Opris  3 , Al Hussein Hamida  4 , Simona Gurzu  5
Affiliations
Free article
Review

Update on the genetic profile of mitral valve development and prolapse

Carmen Elena Opris et al. Pathol Res Pract. 2024 Oct.
Free article

Abstract

The purpose of this review is to present a comprehensive overview of the literature published up to February 2024 on the PubMed database regarding the development of mitral valve disease, with detailed reference to mitral valve prolapse, from embryology to a genetic profile. Out of the 3291 publications that deal with mitral valve embryology, 215 refer to mitral valve genetics and 83 were selected for further analysis. After reviewing these data, we advocate for the importance of a gene-based therapy that should be available soon, to prevent or treat non-invasively the valvular degeneration.

Keywords: Embryology; Genes; Mitral valve prolapse.

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Conflict of interest statement

Declaration of Competing Interest We declare that we are responsible for recognizing any conflict of interest that could bias our work in the acknowledgments, disclosing all financial support and any other personal connections. This paper contains data that have not previously published or not under consideration for publication in other journals.

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