Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study
- PMID: 39182573
- DOI: 10.1016/j.chest.2024.07.171
Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study
Abstract
Background: To our knowledge, no large observational study has compared the incidence and risk factors for extubation failure within 48 h and during ICU stay in the same cohort of unselected critically ill patients with and without obesity.
Research question: What are the incidence and risk factors of extubation failure in patients with and without obesity?
Study design and methods: In the prospective multicenter observational Practices and Risk Factors for Weaning and Extubation Airway Failure in Adult Intensive Care Unit: A Multicenter Trial (FREEREA) study in 26 ICUs, the primary objective was to compare the incidence of extubation failure within 48 h in patients with and without obesity. Secondary objectives were to describe and to identify the independent specific risk factors for extubation failure using first a logistic regression model and second a decision tree analysis.
Results: Of 1,370 extubation procedures analyzed, 288 (21%) were performed in patients with obesity and 1,082 (79%) in patients without obesity. The incidence of extubation failure within 48 h among patients with or without obesity was 23 of 288 (8.0%) vs 118 of 1,082 (11%), respectively (unadjusted OR, 0.71; 95% CI, 0.45-1.13; P = .15); alongside patients with obesity receiving significantly more noninvasive ventilation [87 of 288 (30%) vs 233 of 1,082 (22%); P = .002] and physiotherapy [165 of 288 (57%) vs 527 of 1,082 (49%); P = .02] than patients without obesity. Risk factors for extubation failure also differed according to obesity status: female sex (adjusted OR, 4.88; 95% CI, 1.61-13.9; P = .002) and agitation before extubation (adjusted OR, 6.39; 95% CI, 1.91-19.8; P = .001) in patients with obesity, and absence of strong cough before extubation (adjusted OR, 2.38; 95% CI, 1.53-3.84; P = .0002) and duration of invasive mechanical ventilation before extubation (adjusted OR, 1.03/d; 95% CI, 1.01-1.06; P = .01) in patients without obesity. The decision tree analysis found similar risk factors.
Interpretation: Our findings indicate that anticipation and application of preventive measures for patients with obesity before and after extubation led to similar rates of extubation failure among patients with and without obesity.
Clinical trial registration: ClinicalTrials.gov; No.: NCT02450669; URL: www.
Clinicaltrials: gov.
Keywords: ICU; airway; critical care; extubation; weaning.
Copyright © 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: S. J. reports receiving consulting fees from Drager, Medtronic, Mindray, Fresenius, Baxter, and Fisher & Paykel. A. D. J. reports receiving remuneration for presentations from Medtronic, Drager, and Fisher & Paykel. E. A. has received fees from Gilead Sciences, Alexion, Astellas, MSD, and Drager. J. Pottecher has received fees from Medtronic, Baxter, and Getinge. None declared (M. Capdevila, Y. A., M. Cros, J. Pensier, I. L., C. M., H. Q., R. C., K. A., J.-M. A., C. G., C. P.-B., P. A., A. M.-D., K. L., S. L., G. P., B. C., P. C., C. I., N. M., G. C., L. P.).
