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. 1985 Jan;82(2):479-82.
doi: 10.1073/pnas.82.2.479.

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line

M Wabl, P D Burrows, A von Gabain, C Steinberg

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line

M Wabl et al. Proc Natl Acad Sci U S A. 1985 Jan.

Abstract

Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) per cell generation. This high rate is termed hypermutation.

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