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. 2024 Aug 23;103(34):e39402.
doi: 10.1097/MD.0000000000039402.

Colorectal cancer mortality trend analysis in Montenegro from 1990 to 2018

Mirjana Nedović Vuković  1   2 , Marina Jakšić  2   3 , Brigita Smolović  2   4 , Mileta Golubović  2   5 , Dragan Laušević  2   6
Affiliations

Colorectal cancer mortality trend analysis in Montenegro from 1990 to 2018

Mirjana Nedović Vuković et al. Medicine (Baltimore). .

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer-related death in Europe. This study aimed to investigate CRC mortality trends in Montenegro from 1990 to 2018 and critically review the impact of preventive activities on cancer suppression in this country. We used the national CRC mortality data categorized by sex and age. Mortality rates were age-standardized according to the World Standard Population. The trends were described using regression techniques. In the period from 1990 to 2018, there was a significant increase in CRC mortality (P < .05). The death rates and the number of deaths from CRC were constantly increasing for both the overall level and gender, with the mean annual percentage change for the rates respectively average annual percent change (95% confidence interval-CI): 2.6% (1.9-3.2), 2.6% (1.8-3.5); 2.3% (1.3-3.3), and for the number of cases, respectively: 4.2% (3.5-4.9), 4.3% (3.3-5.3), 4.3% (3.2-5.5). The most affected age groups were 65 to 74 years (33%), followed by those aged 75 to 84 years (25%) and the age group 55 to 64 (22%). In Montenegro, CRC mortality trends are increasing among both men and women over the age of 45. Additional research on the risk factors and mechanisms that contribute to the unfavorable trends in CRC mortality in Montenegro is necessary.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Joinpoint regression analysis of colorectal cancer mortality rate in Montenegro from 1990 to 2018. APC = annual percentage change. *APC was significantly different from zero P < .05.
Figure 2.
Figure 2.
Joinpoint regression analysis of colorectal cancer death cases in Montenegro from 1990 to 2018. APC = annual percentage change. *APC was significantly different from zero P < .05.
Figure 3.
Figure 3.
Distribution of colorectal cancer mortality by age groups in Montenegro, 1990 to 2018.
See this image and copyright information in PMC

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