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. 1985 Jan;34(1):22-8.
doi: 10.1111/j.1600-0609.1985.tb00739.x.

Kinetic evaluation of four Factor VIII concentrates by model-independent methods

M Matucci, A Messori, G Donati-Cori, G Longo, S Vannini, M Morfini, E Tendi, P L Rossi-Ferrini

Kinetic evaluation of four Factor VIII concentrates by model-independent methods

M Matucci et al. Scand J Haematol. 1985 Jan.

Abstract

Single-dose kinetics of 4 Factor VIII concentrates (Kryobulin, Hemofil T, Koate, cryoprecipitate) were studied in 41 patients with haemophilia-A. Model-independent methods were adopted for calculating the kinetic parameters (area under the curve, clearance, area under the moment curve, mean residence time, volume of distribution at steady-state). No substantial difference was observed in the kinetic characteristics of the 4 Factor VIII concentrates. A considerable interindividual variability of the calculated kinetic parameters was demonstrated for all concentrates. Our findings support the need to individualize Factor VIII dosage.

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