Shaping smell: chloride currents dictate the kinetics of olfactory transduction

doi:10.1113/JP287393

. 2024 Oct;602(19):4699-4700.

doi: 10.1113/JP287393. Epub 2024 Aug 26.

Shaping smell: chloride currents dictate the kinetics of olfactory transduction

Zach Fyke^{1

2}, Kai Clane Belonio¹, Joseph D Zak^{1

3}

Affiliations

¹ Department of Biological Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
² Graduate Program in Neuroscience, University of Illinois Chicago, Chicago, Illinois, USA.
³ Department of Psychology, University of Illinois Chicago, Chicago, Illinois, USA.

PMID: 39183670
PMCID: PMC11466708 (available on 2025-10-01)
DOI: 10.1113/JP287393

Shaping smell: chloride currents dictate the kinetics of olfactory transduction

Zach Fyke et al. J Physiol. 2024 Oct.

. 2024 Oct;602(19):4699-4700.

doi: 10.1113/JP287393. Epub 2024 Aug 26.

Authors

Zach Fyke^{1

2}, Kai Clane Belonio¹, Joseph D Zak^{1

3}

Affiliations

¹ Department of Biological Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
² Graduate Program in Neuroscience, University of Illinois Chicago, Chicago, Illinois, USA.
³ Department of Psychology, University of Illinois Chicago, Chicago, Illinois, USA.

PMID: 39183670
PMCID: PMC11466708 (available on 2025-10-01)
DOI: 10.1113/JP287393

No abstract available

Keywords: adaptation; olfaction; sensory transduction.

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Conflict of interest statement

Competing interests

The authors declare no competing interests

Cited by

Amplification of olfactory transduction currents implements sparse stimulus encoding.
Belonio KC, Haile ES, Fyke Z, Vivona L, Konanur V, Zak JD. Belonio KC, et al. bioRxiv [Preprint]. 2024 Oct 12:2024.10.11.617893. doi: 10.1101/2024.10.11.617893. bioRxiv. 2024. Update in: J Neurosci. 2025 Mar 17:e2008242025. doi: 10.1523/JNEUROSCI.2008-24.2025. PMID: 39416025 Free PMC article. Updated. Preprint.
Amplification of olfactory transduction currents implements sparse stimulus encoding.
Belonio KC, Haile ES, Fyke Z, Vivona L, Konanur V, Tulabandhula T, Zak JD. Belonio KC, et al. J Neurosci. 2025 Mar 17;45(18):e2008242025. doi: 10.1523/JNEUROSCI.2008-24.2025. Online ahead of print. J Neurosci. 2025. PMID: 40097179

References

1. Li R-C, Lin C-C, Ren X, Wu JS, Molday LL, Molday RS & Yau K-W (2018). Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci 115, 5570–5575. - PMC - PubMed
1. Lowe G & Gold GH (1993). Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366, 283–286. - PubMed
1. Pietra G, Dibattista M, Menini A, Reisert J & Boccaccio A (2016). The Ca2+-activated Cl− channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. J Gen Physiol 148, 293–311. - PMC - PubMed
1. Reisert J, Pifferi S, Guarneri G, Ricci C, Menini M, Dibattista M (2024) The Ca2+-activated Cl- channel TMEM16B shapes the response time course of olfactory sensory neurons. J Physiol - PMC - PubMed
1. Zak JD, Grimaud J, Li R-C, Lin C-C & Murthy VN (2018). Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons. Sci Rep 8, 10600. - PMC - PubMed

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[1] Li R-C, Lin C-C, Ren X, Wu JS, Molday LL, Molday RS & Yau K-W (2018). Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci 115, 5570–5575. - PMC - PubMed

[2] Li R-C, Lin C-C, Ren X, Wu JS, Molday LL, Molday RS & Yau K-W (2018). Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons. Proc Natl Acad Sci 115, 5570–5575. - PMC - PubMed

[3] Lowe G & Gold GH (1993). Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366, 283–286. - PubMed

[4] Lowe G & Gold GH (1993). Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366, 283–286. - PubMed

[5] Pietra G, Dibattista M, Menini A, Reisert J & Boccaccio A (2016). The Ca2+-activated Cl− channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. J Gen Physiol 148, 293–311. - PMC - PubMed

[6] Pietra G, Dibattista M, Menini A, Reisert J & Boccaccio A (2016). The Ca2+-activated Cl− channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. J Gen Physiol 148, 293–311. - PMC - PubMed

[7] Reisert J, Pifferi S, Guarneri G, Ricci C, Menini M, Dibattista M (2024) The Ca2+-activated Cl- channel TMEM16B shapes the response time course of olfactory sensory neurons. J Physiol - PMC - PubMed

[8] Reisert J, Pifferi S, Guarneri G, Ricci C, Menini M, Dibattista M (2024) The Ca2+-activated Cl- channel TMEM16B shapes the response time course of olfactory sensory neurons. J Physiol - PMC - PubMed

[9] Zak JD, Grimaud J, Li R-C, Lin C-C & Murthy VN (2018). Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons. Sci Rep 8, 10600. - PMC - PubMed

[10] Zak JD, Grimaud J, Li R-C, Lin C-C & Murthy VN (2018). Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons. Sci Rep 8, 10600. - PMC - PubMed

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Shaping smell: chloride currents dictate the kinetics of olfactory transduction

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Shaping smell: chloride currents dictate the kinetics of olfactory transduction

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