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Case Reports
. 2024 Jul 24;16(7):e65272.
doi: 10.7759/cureus.65272. eCollection 2024 Jul.

A Case of Recurrent Liver Injury-Associated Acute Pancreatitis (LIAAP)

Logan Oliver  1 , Chuchu Liu  2 , Brett Sadowski  2
Affiliations
Case Reports

A Case of Recurrent Liver Injury-Associated Acute Pancreatitis (LIAAP)

Logan Oliver et al. Cureus. .

Abstract

Many etiologies of acute liver injury (ALI) include drug-induced liver injury (DILI), viral illness, and autoimmune disease. Acute pancreatitis is an uncommon though significant etiology of ALI caused by inflammation, fluid shifts, and ischemia secondary to microthrombi formation that can progress to liver failure if left untreated. We present a case of hypertriglyceridemia-induced pancreatitis resulting in liver injury-associated acute pancreatitis (LIAAP) and a concurrent consumptive coagulopathy consistent with an ischemic hepatopathy. Through treatment of her pancreatitis with intravenous insulin and plasmapheresis and subsequent transition to an oral regimen for her hypertriglyceridemia upon hospital discharge, the patient demonstrated full resolution of her ALI and coagulopathy. Through this case, we hope to highlight the importance of recognizing LIAAP and its underlying pathogenesis.

Keywords: acute liver injury; acute pancreatitis; disseminated intravascular coagulation (dic); drug-induced liver injury; ischemic hepatopathy.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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