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Case Reports
. 2024 Jul 24;16(7):e65289.
doi: 10.7759/cureus.65289. eCollection 2024 Jul.

IgG4-Related Autoimmune Pancreatitis Mimicking Pancreatic Cancer: A Report of Two Cases

Fatema Mohamed  1 , Balasubramaniam Vijayan  1 , Lokesh Saraswat  2
Affiliations
Case Reports

IgG4-Related Autoimmune Pancreatitis Mimicking Pancreatic Cancer: A Report of Two Cases

Fatema Mohamed et al. Cureus. .

Abstract

IgG4-related autoimmune pancreatitis (AIP) is a rare inflammatory condition characterized by elevated IgG4-positive plasma cells and lymphoplasmacytic infiltration in the pancreas. This disease responds to steroid therapy but can be challenging to differentiate from pancreatic cancer. In this paper, we present two cases of IgG4-related AIP presenting as pancreatic masses. Our aim is to highlight the diagnostic complexities of this condition and emphasize the need for a multidisciplinary approach to avoid unnecessary surgical interventions and ensure appropriate treatment.

Keywords: autoimmune pancreatitis type 1; igg-4-related disease; igg4 disease; igg4-related autoimmune pancreatitis; pancreatic mass.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Abdominal contrast-enhanced computed tomography.
(A and B) Diffuse common bile duct thickening and biliary dilatation. (C) Few peri-pancreatic slightly enlarged nodes.
Figure 2
Figure 2. PET scan images.
(A) Diffuse PET uptake throughout the pancreas. (B) Slightly more intense uptake in the head and uncinate process.
Figure 3
Figure 3. Endoscopic ultrasound showing pancreatic head mass.
Figure 4
Figure 4. CT showing biliary dilatation with common bile duct thickening and abrupt transition and stricturing at the distal end.
Figure 5
Figure 5. PET scan showing pancreatic head and distal common bile duct lesion.
Figure 6
Figure 6. Endoscopic ultrasound.
(A) A heterogeneous lesion at the pancreatic head. (B) Diffuse common bile duct thickening (blue arrow).
See this image and copyright information in PMC

References

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