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Case Reports
. 2024 Feb;17(2):187-190.
doi: 10.5005/jp-journals-10005-2723.

Ewing's Sarcoma of Mandible: A Case Report with Review of Literature

Nicolas Bellut  1 , Claire Manon Lutz  2 , Maria Lesnik  3 , Sophie-Myriam Dridi  4 , Isabelle Aerts  5 , Anne-Laure Ejeil  6
Affiliations
Case Reports

Ewing's Sarcoma of Mandible: A Case Report with Review of Literature

Nicolas Bellut et al. Int J Clin Pediatr Dent. 2024 Feb.

Abstract

Background: Ewing sarcoma (ES), a rare malignancy, comprises whatever the age, 4-15% of all primary bone tumors. It represents 1% of all malignant tumors in children and is the fourth most common bone malignancy after myeloma, osteosarcoma, and chondrosarcoma.

Case description: A 12-year-old boy came to the Oral Surgery Department of Bretonneau Hospital referred by his dentist with a rapidly evolving swelling in the left mandibula for 6 weeks, which was initially diagnosed as a facial cellulitis. Cone beam computed tomography (CBCT) showed a poorly defined, expansile, and osteolytic tumor on the left side of the mandible. Clinical and radiographic findings were in favor of an aggressive primitive bone tumor. A mandibular biopsy under general anesthesia was performed in the Department of Surgical Oncology at Institut Curie in Paris, revealing an ES.

Conclusion: Mandibular ES can mimic dental infections when swelling is the main clinical manifestation, which can lead to a delayed diagnosis. A correlation between clinical, radiological, histopathological, and immunohistochemical with cytogenetics is needed to confirm the diagnosis. Moreover, smaller tumors have better survival.Dentists must therefore be aware of the clinical signs of ES in order to quickly refer patients to a specialized department.

How to cite this article: Bellut N, Lutz CM, Lesnik M, et al. Ewing's Sarcoma of Mandible: A Case Report with Review of Literature. Int J Clin Pediatr Dent 2024;17(2):187-190.

Keywords: Case report; Ewing sarcoma; Head and neck sarcoma; Mandibular sarcoma; Pediatric sarcoma.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Fig. 1:
Fig. 1:
Extraoral view
Fig. 2:
Fig. 2:
Intraoral examination—buccal view
Fig. 3:
Fig. 3:
Intraoral examination—lingual view
Fig. 4:
Fig. 4:
Orthopantomogram radiograph
Fig. 5:
Fig. 5:
Baseline CBCT
Fig. 6:
Fig. 6:
Cytological examination—sheets of small round cells with inconspicuous cytoplasm
Fig. 7:
Fig. 7:
Anatomopathological examination—proliferation of small undifferentiated basophilic round cells from medium to large size with amphophilic cytoplasm with indistinct boundaries and pepper-and-salt chromatin core, sometimes nucleolated. Mitotic activity is indistinct due to significant crush artifacts. The stroma is fibrous, sometimes desmoplastic, isolating sheets of tumoral cells
Fig. 8:
Fig. 8:
End of treatment CBCT scan
See this image and copyright information in PMC

References

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