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. 1985 Feb;28(2):174-81.
doi: 10.1002/art.1780280212.

Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis

G Husby, R C Williams Jr

Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis

G Husby et al. Arthritis Rheum. 1985 Feb.

Abstract

Synovial tissues were studied, using immunofluorescence techniques, for localization of lymphocytic infiltrates and immune reactants, including C3, C5b-9, C9, and Ia antigen. Tissue distribution of interleukin-2 (IL-2) and gamma-interferon was also determined, using mouse monoclonal antibodies. IL-2 was found in association with OKT8 and OKT4 T cells, and gamma-interferon was noted in association with T cells, B cells, and macrophages. Staining both for IL-2 and for gamma-interferon was surprisingly faint in view of the intensity of lymphocytic infiltration.

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