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. 2024 Dec;48(6):4061-4065.
doi: 10.1007/s11259-024-10507-9. Epub 2024 Aug 26.

Prolonged detection of BPV2 in urine and blood of papillomatosis-affected cattle not grazing bracken fern

Elias Tibúrcio-Júnior  1 , Patricia G Carrazzoni  2 , Fernando Tenorio-Filho  2 , Nayara E Pontes  1 , Ryan V Alves  3 , Antonio Carlos de Freitas  4 , Maria Angélica Ramos Silva  1   3
Affiliations

Prolonged detection of BPV2 in urine and blood of papillomatosis-affected cattle not grazing bracken fern

Elias Tibúrcio-Júnior et al. Vet Res Commun. 2024 Dec.

Abstract

BPV-2 infection can cause bladder infections in cattle that, when associated with bracken fern consumption, can progress to cancerous bladder tumors and also present as bovine enzootic hematuria (BEH). This study aimed to evaluate the prolonged natural BPV-2 infection in the blood and urine of cattle, excluding bracken fern consumption. Thirteen Girolando papillomatosis-affected cattle with no bracken fern contact history were monitored for 20 months. Blood, urine, and wart samples were collected for BPV-2 detection and clinical laboratory analyses. All animals showed the presence of BPV-2 in papillomas and blood, and 92.85% showed BPV-2 in urine, suggesting viral dissemination in the urinary tract. Despite all animals being infected with BPV-2, none showed BEH signs during the study. Thus, it was observed that BPV-2 infection alone didn't induce BEH over 20 months, implying a complex interaction with environmental factors or genetic predisposition. This underlines bracken fern consumption's critical role in urinary bladder carcinogenesis. The study underscores BEH's pathogenesis complexity, advocating longitudinal studies to comprehend BPV-2's role fully.

Keywords: Bovine enzootic hematuria (BEH); Bovine papillomavirus (BPV); Bracken fern.

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References

    1. Alcantara BK, Lunardi M, Agnol AMD, Alfieri AF, Alfieri AA (2021) Detection and quantification of the E6 oncogene in bovine papillomavirus types 2 and 13 from urinary bladder lesions of cattle. Front Vet Sci 8:673189. https://doi.org/10.3389/fvets.2021.673189 - DOI - PubMed - PMC
    1. Araldi RP et al (2017) Papillomaviruses: a systematic review. Gen Mol Bio 40(1):1–21. https://doi.org/10.1590/1678-4685-GMB-2016-0128 - DOI
    1. Bocaneti F et al (2014) Bovine papillomavirus: new insights into an old disease. Transb Em Dis 63(1):1–10
    1. Borzacchiello G, Iovane G, Marcante M et al (2003) Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows. J Gen Virol 84(11):2921–2926. https://doi.org/10.1099/vir.0.19412-0 - DOI - PubMed
    1. Borzacchiello G, Russo V, Gentile F, Roperto F, Venuti A, Nitsch L, Campo MS, Roperto S (2006) Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours. Onc 25(8):1251–1260. https://doi.org/10.1038/sj.onc.1209152 - DOI

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