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Multicenter Study
. 2024 Dec;193(6):2661-2667.
doi: 10.1007/s11845-024-03774-7. Epub 2024 Aug 26.

Upper endoscopy in elderly patients: a multicentre, cross-sectional study

Angelo Zullo  1 , Vincenzo De Francesco  2 , Arnaldo Amato  3 , Irene Bergna  3 , Emanuele Bendia  4 , Giorgia Giorgini  4 , Elisabetta Buscarini  5 , Guido Manfredi  5 , Sergio Cadoni  6 , Renato Cannizzaro  7 , Stefano Realdon  7 , Mario Ciuffi  8 , Orazio Ignomirelli  8 , Paola Da Massa Carrara  9 , Giovanni Finucci  9 , Antonietta Di Somma  10 , Chiara Frandina  11 , Mariafrancesca Loria  11 , Francesca Galeazzi  12 , Francesco Ferrara  12 , Carlo Gemme  13 , Noemi Sara Bertetti  13 , Federica Gentili  14 , Antonio Lotito  14 , Bastianello Germanà  15 , Nunzia Russo  15 , Giuseppe Grande  16 , Rita Conigliaro  16 , Federico Cravero  17 , Giovanna Venezia  17 , Riccardo Marmo  18 , Piera Senneca  18 , Angelo Milano  19 , Konstantinos Efthymakis  19 , Fabio Monica  10   20 , Paolo Montalto  21 , Mario Lombardi  21 , Olivia Morelli  22 , Danilo Castellani  22 , Daniela Nigro  23 , Roberto Festa  23 , Sergio Peralta  24 , Maria Grasso  24 , Antonello Privitera  25 , Maria Emanuela Di Stefano  25 , Giuseppe Scaccianoce  26 , Mariangela Loiacono  26 , Sergio Segato  27 , Marco Balzarini  27 , Paolo Usai-Satta  28 , Mariantonia Lai  28 , Francesca Fortunato  29 , Raffaele Manta  9
Affiliations
Multicenter Study

Upper endoscopy in elderly patients: a multicentre, cross-sectional study

Angelo Zullo et al. Ir J Med Sci. 2024 Dec.

Erratum in

  • Correction to: Upper endoscopy in elderly patients: A multicentre, cross‑sectional study.
    Zullo A, De Francesco V, Amato A, Bergna I, Bendia E, Giorgini G, Buscarini E, Manfredi G, Cadoni S, Cannizzaro R, Realdon S, Ciuffi M, Ignomirelli O, Da Massa Carrara P, Finucci G, Di Somma A, Frandina C, Loria M, Galeazzi F, Ferrara F, Gemme C, Bertetti NS, Gentili F, Lotito A, Germanà B, Russo N, Grande G, Conigliaro R, Cravero F, Venezia G, Marmo R, Senneca P, Milano A, Efthymakis K, Monica F, Montalto P, Lombardi M, Morelli O, Castellani D, Nigro D, Festa R, Peralta S, Grasso M, Privitera A, Di Stefano ME, Scaccianoce G, Loiacono M, Segato S, Balzarini M, Usai-Satta P, Lai M, Fortunato F, Manta R. Zullo A, et al. Ir J Med Sci. 2025 Feb;194(1):401-402. doi: 10.1007/s11845-024-03814-2. Ir J Med Sci. 2025. PMID: 39417924 No abstract available.
  • Correction to: Upper endoscopy in elderly patients: a multicentre, cross‑sectional study.
    Zullo A, De Francesco V, Amato A, Bergna I, Bendia E, Giorgini G, Buscarini E, Manfredi G, Cadoni S, Cannizzaro R, Realdon S, Ciuffi M, Ignomirelli O, Da Massa Carrara P, Finucci G, Di Somma A, Frandina C, Loria M, Galeazzi F, Ferrara F, Gemme C, Bertetti NS, Gentili F, Lotito A, Germanà B, Russo N, Grande G, Conigliaro R, Cravero F, Venezia G, Marmo R, Senneca P, Milano A, Efthymakis K, Monica F, Montalto P, Lombardi M, Morelli O, Castellani D, Nigro D, Festa R, Peralta S, Grasso M, Privitera A, Di Stefano ME, Scaccianoce G, Loiacono M, Segato S, Balzarini M, Usai-Satta P, Lai M, Fortunato F, Manta R. Zullo A, et al. Ir J Med Sci. 2025 Jun;194(3):1187-1188. doi: 10.1007/s11845-025-03957-w. Ir J Med Sci. 2025. PMID: 40214846 No abstract available.

Abstract

Background: Both macroscopic and histological lesions are frequently detected at upper endoscopy in elderly patients. We assessed the prevalence of main endoscopic and histological alterations in elderly (> 65 years old) patients.

Methods: In this study, clinical, endoscopic and histological features of patients referred for upper endoscopy in clinical practice were retrieved. Both univariate and multivariate analyses were executed. Comparisons with previous data were performed.

Results: A total of 1336 underwent upper endoscopy in the 28 participating centres. At endoscopy, at least one macroscopic lesion was present in overall 420 (31.4%) patients. Erosive gastritis (13.3%) and erosive oesophagitis (9.8%) were the most prevalent lesions, whilst Barrett's oesophagus, gastric ulcer, duodenal ulcer and erosive duodenitis were observed in 1.8%, 2%, 1.4% and 3.1% patients, respectively. Nine (0.6%) cases of oesophageal, 25 (1.8%) gastric and 2 (0.1%) duodenal neoplasia were detected. At histology, Helicobacter pylori infection was diagnosed in 99 (15.9%) patients, and extensive precancerous lesions on gastric mucosa were detected in 80 (14.5%) patients. Endoscopic lesions were more frequent in males, at first endoscopy and in those with alarm symptoms and lower during PPI therapy. At multivariate analysis, PPI therapy significantly reduced the probability of finding endoscopic lesions (OR: 0.68, 95% CI: 0.46-0.99; P = 0.04), whilst neoplastic lesions were associated with presence of alarm symptoms (OR: 1.5, 95% CI: 1.1-2.1; P = 0.005).

Conclusions: We found that the frequency of erosive and neoplastic lesions remained high in elderly patients, whilst the prevalence of both H. pylori infection and peptic ulcer was decreased.

Keywords: Elderly; Erosion; Histology; Neoplasia; Ulcer; Upper endoscopy.

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Conflict of interest statement

Declarations. Ethical approval: Since no identification of patients was allowed, no experimental drugs were administered, no additional costs or procedures for the patients were required, and no funds were received. The Investigational Review Boards of Nuovo Regina Margherita Hospital waived formal approval for this retrospective analysis. Consent to participate: Patients signed informed consent for both procedure and anonymous use of their data for scientific purposes. Competing interests: The authors declare no competing interests.

References

    1. Franceschi M, Di Mario F, Leandro G et al (2009) Acid-related disorders in the elderly. Best Pract Res Clin Gastroenterol 23(6):839–848. https://doi.org/10.1016/j.bpg.2009.10.004 - DOI - PubMed
    1. Newton J (2005) Effect of age-related changes in gastric physiology on tolerability of medications for older people. Drugs Aging 22:655–661. https://doi.org/10.2466/pr0.96.3.701-706 - DOI - PubMed
    1. Stillhart C, Asteriadis A, Bocharova E et al (2023) The impact of advanced age on gastrointestinal characteristics that are relevant to oral drug absorption: An AGePOP review. Eur J Pharm Sci 187:106452. https://doi.org/10.1016/j.ejps.2023.106452 - DOI - PubMed
    1. Pilotto A, Franceschi M (2014) Helicobacter pylori infection in older people. World J Gastroenterol 20(21):6364–6373. https://doi.org/10.3748/wjg.v20.i21.6364 - DOI - PubMed - PMC
    1. Bjarnason I, Scarpignato C, Holmgren E et al (2018) Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs. Gastroenterology 154:500–514. https://doi.org/10.1053/j.gastro.2017.10.049 - DOI - PubMed

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