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. 1985 Feb;15(2):196-9.
doi: 10.1002/eji.1830150217.

Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells

Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells

I Ando et al. Eur J Immunol. 1985 Feb.

Abstract

The tumor promoter 12-O-tetradecanoylphorbol 13-acetate induces the expression of the interleukin 2 receptor and the disappearance of the T3 complex in a T cell hybridoma, T cell clones, thymic and peripheral T cells and T cell tumors. These changes are accompanied by an increased sensitivity to interleukin 2 and antigen-specific unresponsiveness in T cell clones.

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