Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells
- PMID: 3918872
- DOI: 10.1002/eji.1830150217
Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells
Abstract
The tumor promoter 12-O-tetradecanoylphorbol 13-acetate induces the expression of the interleukin 2 receptor and the disappearance of the T3 complex in a T cell hybridoma, T cell clones, thymic and peripheral T cells and T cell tumors. These changes are accompanied by an increased sensitivity to interleukin 2 and antigen-specific unresponsiveness in T cell clones.
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