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Review
. 2022 Dec 27;1(1):e20220014.
doi: 10.1002/SMMD.20220014. eCollection 2022 Dec.

Functional biomaterials for osteoarthritis treatment: From research to application

Yang Lei  1 , Qingfei Zhang  1 , Gaizheng Kuang  1 , Xiaochen Wang  1   2   3 , Qihui Fan  2 , Fangfu Ye  1   2   3
Affiliations
Review

Functional biomaterials for osteoarthritis treatment: From research to application

Yang Lei et al. Smart Med. .

Abstract

Osteoarthritis (OA) is a common disease that endangers millions of middle-aged and elderly people worldwide. Researchers from different fields have made great efforts and achieved remarkable progress in the pathogenesis and treatment of OA. However, there is still no cure for OA. In this review, we discuss the pathogenesis of OA and summarize the current clinical therapies. Moreover, we introduce various natural and synthetic biomaterials for drug release, cartilage transplantation, and joint lubricant during the OA treatment. We also present our perspectives and insights on OA treatment in the future. We hope that this review will foster communication and collaboration among biological, clinical, and biomaterial researchers, paving the way for OA therapeutic breakthroughs.

Keywords: biomaterials; exosome therapy; hydrogel; osteoarthritis; stem cell therapy.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Fangfu Ye is a member of the Smart Medicine editorial board.

Figures

FIGURE 1
FIGURE 1
The main content of this review includes Osteoarthritis (OA) pathogenesis, clinical treatment strategies, and functional biomaterials applied in OA therapy.
FIGURE 2
FIGURE 2
The inducing factors of Osteoarthritis include obesity, age, genetic factor, joint trauma, inflammation, etc. Reproduced under terms of the CC‐BY license. Copyright 2021, The Authors, published by Hindawi Publishing Corporation.
FIGURE 3
FIGURE 3
Clinical Osteoarthritis management. Traditional treatments include education, lifestyle changes, physical and adjunct therapy, drug therapy, and surgical medication. New biotech treatments include stem cell therapy, exosome therapy, cartilage transplantation, growth factor therapy, etc.
FIGURE 4
FIGURE 4
Biomaterials applied for osteoarthritis treatment include polysaccharide hydrogel, natural protein hydrogel, synthetic hydrogel, synthetic polymer, acellular matrix, inorganic materials, liposomes, etc.
FIGURE 5
FIGURE 5
Biomaterials for Osteoarthritis treatment. (A) Ice‐inspired lubricant drug delivery particle derived from HA. Reproduced with permission. Copyright 2021, American Chemical Society. (B) GelMA microspheres with enhanced lubrication and controllable drug release. Reproduced with permission. Copyright 2021, The Authors, published by Elsevier. (C) HA‐modified LGA particles. Reproduced with permission. Copyright 2019, Elsevier. (D) Euryale ferox seed‐inspired superlubricated nanoparticles. Reproduced with permission. Copyright 2019, John Wiley and Sons.
See this image and copyright information in PMC

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