Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation

Affiliations

¹ Section of Nephrology, Department of Pediatrics Yale University School of Medicine New Haven CT USA.
² Clinical and Translational Research Accelerator, Department of Medicine Yale University School of Medicine New Haven CT USA.
³ Department of Ophthalmology, David Geffen School of Medicine Stein Eye Institute, University of California Los Angeles CA USA.
⁴ Department of Ophthalmology and Visual Science Yale University School of Medicine New Haven CT USA.
⁵ Division of Cardiology, Department of Medicine, Sulpizio Cardiovascular Center University of California, San Diego La Jolla CA USA.
⁶ Department of Ophthalmology University of California San Diego La Jolla CA USA.
⁷ Division of Cardiology, Department of Medicine Yale University School of Medicine New Haven CT USA.
⁸ Greater Los Angeles VA Healthcare Center Los Angeles CA USA.
⁹ Department of Pathology Yale University School of Medicine New Haven CT USA.
¹⁰ Yale Cancer Center Yale University New Haven CT USA.

Christine Y Bakhoum et al. J Am Heart Assoc. 2024.

. 2024 Sep 3;13(17):e035079.

doi: 10.1161/JAHA.123.035079. Epub 2024 Aug 27.

¹ Section of Nephrology, Department of Pediatrics Yale University School of Medicine New Haven CT USA.
² Clinical and Translational Research Accelerator, Department of Medicine Yale University School of Medicine New Haven CT USA.
³ Department of Ophthalmology, David Geffen School of Medicine Stein Eye Institute, University of California Los Angeles CA USA.
⁴ Department of Ophthalmology and Visual Science Yale University School of Medicine New Haven CT USA.
⁵ Division of Cardiology, Department of Medicine, Sulpizio Cardiovascular Center University of California, San Diego La Jolla CA USA.
⁶ Department of Ophthalmology University of California San Diego La Jolla CA USA.
⁷ Division of Cardiology, Department of Medicine Yale University School of Medicine New Haven CT USA.
⁸ Greater Los Angeles VA Healthcare Center Los Angeles CA USA.
⁹ Department of Pathology Yale University School of Medicine New Haven CT USA.
¹⁰ Yale Cancer Center Yale University New Haven CT USA.

No abstract available

Keywords: RIPLs; atrial fibrillation; optical coherence tomography; retinal ischemic perivascular lesion; stroke.

References

1. Brundel B, Ai X, Hills MT, Kuipers MF, Lip GY, de Groot NM. Atrial fibrillation. Nat Rev Dis Primers. 2022;8:21. doi: 10.1038/s41572-022-00347-9 - DOI - PubMed
1. Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor‐based approach: the Euro Heart Survey on Atrial Fibrillation. Chest. 2010;137:263–272. doi: 10.1378/chest.09-1584 - DOI - PubMed
1. Chen LY, Norby FL, Chamberlain AM, MacLehose RF, Bengtson LG, Lutsey PL, Alonso A. CHA2DS2‐VASc score and stroke prediction in atrial fibrillation in whites, blacks, and Hispanics. Stroke. 2019;50:28–33. doi: 10.1161/STROKEAHA.118.021453 - DOI - PMC - PubMed
1. Bakhoum CY, Madala S, Lando L, Yarmohammadi A, Long CP, Miguez S, Chan AX, Singer M, Jin A, Steren BJ, et al. Retinal ischemic perivascular lesions in individuals with atrial fibrillation. J Am Heart Assoc. 2023;12:e028853. doi: 10.1161/JAHA.122.028853 - DOI - PMC - PubMed
1. Long CP, Chan AX, Bakhoum CY, Toomey CB, Madala S, Garg AK, Freeman WR, Goldbaum MH, DeMaria AN, Bakhoum MF. Prevalence of subclinical retinal ischemia in patients with cardiovascular disease‐a hypothesis driven study. E Clin Med. 2021;33:100775. doi: 10.1016/j.eclinm.2021.100775 - DOI - PMC - PubMed