Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Feb 1;161(2):323-31.
doi: 10.1084/jem.161.2.323.

Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF

P P Chen, S Fong, R A Houghten, D A Carson

Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF

P P Chen et al. J Exp Med. .

Abstract

Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an 'epibody'. We describe the induction of a similar epibody by immunization with a synthetic peptide (corresponding to one hypervariable region of the IgM-RF Glo). The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon.

PubMed Disclaimer

References

    1. J Immunol. 1983 Aug;131(2):719-24 - PubMed
    1. Biochemistry. 1968 Apr;7(4):1261-4 - PubMed
    1. J Exp Med. 1983 Aug 1;158(2):529-45 - PubMed
    1. Eur J Immunol. 1983 Nov;13(11):890-4 - PubMed
    1. J Immunol. 1982 Mar;128(3):1176-80 - PubMed

Publication types

MeSH terms