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. 2024 Sep;47(9):665-666.
doi: 10.1016/j.tins.2024.08.005. Epub 2024 Aug 26.

From synapse to sensation: the role of circTulp4

Juli Wang  1 , Irina Voineagu  2
Affiliations

From synapse to sensation: the role of circTulp4

Juli Wang et al. Trends Neurosci. 2024 Sep.

Abstract

Recent work by Giusti and colleagues showed that circTulp4 modulates excitatory synaptic strength. Knocking down circTulp4 disrupts the excitation-inhibition (E/I) balance in mice and leads to hypersensitivity toward aversive stimuli. These observations update our appreciation of the functions of circular (circ)RNA in the nervous system and their potential implication in neurodevelopmental and neuropsychiatric disorders.

Keywords: aversive stimuli; circular RNA; pyramidal neurons; synaptic strength.

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Conflict of interest statement

Declaration of interests The authors declare no competing or financial interests related to this work.

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