Engineered parasite delivers proteins to the brain

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Sarah Crunkhorn. Nat Rev Drug Discov. 2024 Oct.

. 2024 Oct;23(10):740.

doi: 10.1038/d41573-024-00137-w.

No abstract available

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Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons.
Bracha S, Johnson HJ, Pranckevicius NA, Catto F, Economides AE, Litvinov S, Hassi K, Rigoli MT, Cheroni C, Bonfanti M, Valenti A, Stucchi S, Attreya S, Ross PD, Walsh D, Malachi N, Livne H, Eshel R, Krupalnik V, Levin D, Cobb S, Koumoutsakos P, Caporale N, Testa G, Aguzzi A, Koshy AA, Sheiner L, Rechavi O. Bracha S, et al. Nat Microbiol. 2024 Aug;9(8):2051-2072. doi: 10.1038/s41564-024-01750-6. Epub 2024 Jul 29. Nat Microbiol. 2024. PMID: 39075233 Free PMC article.

1. Bracha, S. et al. Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nat. Microbiol. https://doi.org/10.1038/s41564-024-01750-6 (2024)