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. 2023 Oct:50:10.22489/cinc.2023.137.
doi: 10.22489/cinc.2023.137. Epub 2023 Dec 26.

Uncertainty Quantification of Fiber Orientation and Epicardial Activation

Lindsay C Rupp  1   2   3 , Anna Busatto  1   2   3 , Jake A Bergquist  1   2   3 , Karli Gillette  4 , Akil Narayan  1   5 , Gernot Plank  4 , Rob S MacLeod  1   2   3
Affiliations

Uncertainty Quantification of Fiber Orientation and Epicardial Activation

Lindsay C Rupp et al. Comput Cardiol (2010). 2023 Oct.

Abstract

Predictive models and simulations of cardiac function require accurate representations of anatomy, often to the scale of local myocardial fiber structure. However, acquiring this information in a patient-specific manner is challenging. Moreover, the impact of physiological variability in fiber orientation on simulations of cardiac activation is poorly understood. To explore these effects, we implemented bi-ventricular activation simulations using rule-based fiber algorithms and robust uncertainty quantification techniques to generate detailed maps of model variability. Specifically, we utilized polynomial chaos expansion, enabling efficient exploration with reduced computational demand through an emulator function approximating the underlying forward model. Our study focused on examining the epicardial activation sequences of the heart in response to six stimuli locations and five metrics of activation. Our findings revealed that physiological variability in fiber orientation does not significantly affect the location of activation features, but it does impact the overall spread of activation. We observed low variability near the earliest activation sites, but high variability across the rest of the epicardial surface. We conclude that the level of accuracy of myocardial fiber orientation required for simulation depends on the specific goals of the model and the related research or clinical goals.

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Figures

Figure 1:
Figure 1:
Uncertainty quantification of epicardial activation sequences. The top panel (A) shows the epicardial activation times for epicardial (left) and endocardial (right) apex stimuli locations. The middle panel (B) shows the activation sequence for epicardial (left) and endocardial (right) left ventricular free wall stimuli locations. The bottom panel (C) shows the activation sequence for epicardial (left) and endocardial (right) right ventricular free wall stimuli locations. For each panel, row one shows the mean activation sequence and row two shows the standard deviation of the activation sequence. Each panel shows views from three perspectives along the long axis of the heart: apical, left lateral, and right lateral side. The orange line(s) in panel B are an approximation of the breakthrough site orientation.
See this image and copyright information in PMC

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