Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 14;30(30):3609-3624.
doi: 10.3748/wjg.v30.i30.3609.

Bibliometric study of sepsis-associated liver injury from 2000 to 2023

Zheng Zhang  1 , Xiao-Jiao Tan  1 , Hai-Qing Shi  1 , Huan Zhang  1 , Jian-Bo Li  1 , Xue-Lian Liao  1   2
Affiliations

Bibliometric study of sepsis-associated liver injury from 2000 to 2023

Zheng Zhang et al. World J Gastroenterol. .

Abstract

Background: Sepsis-associated liver injury (SLI) is a severe and prevalent complication of sepsis.

Aim: To explore the literature on SLI via a bibliometric approach.

Methods: Reviews and articles correlated with SLI published from January 1, 2000 to October 28, 2023 were searched from the Web of Science Core Collection. Then, the searched data were analyzed using VOSviewer, CiteSpace, and R language.

Results: There were 787 publications involved in this paper, comprising 745 articles and 42 reviews. China, the United States, and Germany are the primary publication sources in this area. Studies related to SLI primarily focused on mechanisms of pathogenesis, as evidenced by analyzing keywords, references, and the counting of original research. These studies mainly involved tumor necrosis factor alpha, inflammation, oxidative stress, and nuclear factor-kappa B.

Conclusion: There is significant growth in the research on SLI. Current investigations primarily involve basic experiments that aimed at uncovering pathogenic mechanisms. According to the analyzed literature, the identified pathogenic mechanisms and potential therapeutic targets serve as the foundation for translating findings from basic research to clinical applications.

Keywords: Bibliometric analysis; Cite space; Liver injury; Sepsis; VOS viewer.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Flowchart showing literature inclusion, exclusion and analysis process.
Figure 2
Figure 2
Numbers of publications on sepsis-associated liver injury by year.
Figure 3
Figure 3
Publication count and collaboration network by country. A: The world map labeled with the country; B: Publication numbers by country; C: Co-authorship among countries that published at least 10 papers. Each node represented a country, and the green color ring represented publications in a specific year. Purple rings indicated high centrality.
Figure 4
Figure 4
Institutional analysis. A: The top 10 institutions in term of publications; B: Distribution map and collaboration network among institutions. The map shows active cooperation among institutions, with thicker lines representing closer collaboration.
Figure 5
Figure 5
Journal analysis. A: Co-citation map of journal with the threshold of 15 times. Each node represents a journal; B: Dual-map overlay of journals in which research was published (left) or cited (right). Colors distinguished the disciplines, and the thickness of the lines represented a closer alignment in research content.
Figure 6
Figure 6
The top 20 references with the strongest citation bursts.
Figure 7
Figure 7
The mapping on authors of sepsis-associated liver injury. The nodes represent authors, and the size of the node reflects the co-citation frequency of the author’s published articles.
Figure 8
Figure 8
Keyword analysis. A: A visual map of keywords used at least 30 times; The node size represents the keywords’ frequency, while the lines represent their correlations; B: Top 20 keywords with the strongest citation bursts by year. TNF-α: Tumor necrosis factor alpha; NF-κB: Nuclear factor-kappa B; CLP: Cecal ligation and puncture; LPS: Lipopolysaccharides.
See this image and copyright information in PMC

References

    1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA. 2016;315:801–810. - PMC - PubMed
    1. Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, Fleischmann-Struzek C, Machado FR, Reinhart KK, Rowan K, Seymour CW, Watson RS, West TE, Marinho F, Hay SI, Lozano R, Lopez AD, Angus DC, Murray CJL, Naghavi M. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200–211. - PMC - PubMed
    1. Strnad P, Tacke F, Koch A, Trautwein C. Liver - guardian, modifier and target of sepsis. Nat Rev Gastroenterol Hepatol. 2017;14:55–66. - PubMed
    1. Blanco J, Muriel-Bombín A, Sagredo V, Taboada F, Gandía F, Tamayo L, Collado J, García-Labattut A, Carriedo D, Valledor M, De Frutos M, López MJ, Caballero A, Guerra J, Alvarez B, Mayo A, Villar J Grupo de Estudios y Análisis en Cuidados Intensivos. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care. 2008;12:R158. - PMC - PubMed
    1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546–1554. - PubMed