Response to the letter to the editor: Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris

Ehab A Salama^{1

2}, Yehia Elgammal^{3

4}, Aruna Wijeratne⁵, Nadia A Lanman^{6

7}, Sagar M Utturkar⁸, Atena Farhangian⁹, Jianing Li¹⁰, Brigitte Meunier¹¹, Tony R Hazbun^{12

13}, Mohamed N Seleem^{14

15}

Affiliations

¹ Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
² Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
³ Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
⁴ Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
⁵ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁶ Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.
⁷ Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
⁸ Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.
⁹ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
¹⁰ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
¹¹ Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.
¹² Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.
¹³ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
¹⁴ Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
¹⁵ Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

PMID: 39193644
PMCID: PMC11382729
DOI: 10.1080/22221751.2024.2396869

Response to the letter to the editor: Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris

Ehab A Salama et al. Emerg Microbes Infect. 2024 Dec.

. 2024 Dec;13(1):2396869.

doi: 10.1080/22221751.2024.2396869. Epub 2024 Sep 8.

Authors

Affiliations

¹ Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
² Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
³ Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
⁴ Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
⁵ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁶ Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.
⁷ Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
⁸ Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.
⁹ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
¹⁰ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
¹¹ Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.
¹² Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.
¹³ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
¹⁴ Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
¹⁵ Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

PMID: 39193644
PMCID: PMC11382729
DOI: 10.1080/22221751.2024.2396869

No abstract available

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References

1. Zhu M, Wang H, Zhang Y, et al. Letter to the editor: lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug–resistant Candida auris. Emerg Microbes Infect. 2024;13(1). doi:10.1080/22221751.2024.2356144 - DOI
1. Salama EA, Elgammal Y, Wijeratne A, et al. . Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris. Emerg Microbes Infect. 2024;13:2322649. doi:10.1080/22221751.2024.2322649 - DOI - PMC - PubMed
1. Rybniker J, Vocat A, Sala C, et al. . Lansoprazole is an antituberculous prodrug targeting cytochrome bc1. Nat Commun. 2015;6:7659. doi:10.1038/ncomms8659 - DOI - PMC - PubMed
1. Gao L, Xia X, Gong X, et al. . In vitro interactions of proton pump inhibitors and azoles against pathogenic fungi. Front Cell Infect Microbiol. 2024;14:1296151. doi:10.3389/fcimb.2024.1296151 - DOI - PMC - PubMed
1. Yi M, Niu M, Zhang J, et al. . Combine and conquer: manganese synergizing anti-TGF-beta/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers. J Hematol Oncol. 2021;14:146. doi:10.1186/s13045-021-01155-6 - DOI - PMC - PubMed

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Response to the letter to the editor: Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris

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Response to the letter to the editor: Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris

Authors

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References

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Substances

Grants and funding

LinkOut - more resources

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