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. 2024 Oct;38(9):1033-1041.
doi: 10.1177/02692163241269794. Epub 2024 Aug 28.

Palliative care in patients with hepatocellular carcinoma: Results from a survey among hepatologists and palliative care physicians

Massimo Iavarone  1   2 , Lorenzo Canova  1   3 , Eleonora Alimenti  1 , Alessio Aghemo  4   5 , Diego Taveggia  6 , Gino Gobber  7 , Giuseppe Cabibbo  8 , Simone Veronese  9 , Vincenza Calvaruso  8 , Luciano Orsi  10 , Paolo Caraceni  11   12 , Pietro Lampertico  1   2 ; Italian Association for the Study of the Liver (AISF) and Italian Society of Palliative Care (SICP)
Affiliations

Palliative care in patients with hepatocellular carcinoma: Results from a survey among hepatologists and palliative care physicians

Massimo Iavarone et al. Palliat Med. 2024 Oct.

Abstract

Background: Delays and limitations of palliative care in patients with liver transplantation-ineligible end-stage hepatocellular carcinoma according to Barcelona Clinic Liver Cancer staging system may be explained by different perceptions between hepatologists and palliative care physicians in the absence of shared guidelines.

Aim: To assess physicians' attitudes toward palliative care in end-stage hepatocellular carcinoma and to understand what the obstacles are to more effective management and co-shared between palliative care physicians and hepatologists.

Design: Members of the Italian Association for the Study of Liver Disease and the Italian Society of Palliative Care were invited to a web-based survey to investigate practical management attitude for patients with liver transplant-ineligible end-stage hepatocellular carcinoma.

Participants: Physician members of the of the two associations, representing several hospitals and services in the country.

Results: Ninety-seven hepatologists and 70 palliative care physicians completed the survey: >80% regularly follow 1-19 patients; 58% of hepatologists collaborate with palliative care physicians in the management of patients, 55% of palliative care physicians take care of patients without the aid of hepatologists. Management of cirrhosis differed significantly between the two groups in terms of prescription of albumin, esophagogastroduodenoscopy, anti-viral treatment, anticoagulation, indication to paracentesis and management of encephalopathy. Full-dose acetaminophen is widely used among hepatologists, while opioids are commonly used by both categories, at full dosage, regardless of liver function.

Conclusions: This survey highlights significant differences in the approach to patients with liver transplantation-ineligible end-stage hepatocellular carcinoma, reinforcing the need for shared guidelines and further studies on palliative care in the setting.

Keywords: Liver cancer; albumin; cirrhosis; liver transplantation; pain.

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Conflict of interest statement

Declaration of conflicting interestThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: M. Iavarone: Advisory Board/Speaker Bureau for Bayer, Gilead Sciences, BMS, Janssen, Ipsen, MSD, BTG-Boston Scientific, AbbVie, Guerbet, EISAI, Roche, Astra-Zeneca; A. Aghemo: Advisory Board/Speaker Bureau for GILEAD SCIENCES, ABBVIE, MSD, MYLAN, ALFASIGMA, SOBI, INTERCEPT; P. Lampertico: Advisory Board/Speaker Bureau for BMS, ROCHE, GILEAD SCIENCES, GSK, ABBVIE, MSD, ARROWHEAD, ALNYLAM, JANSSEN, SBRING BANK, MYR, EIGER, ALIGOS, ANTIOS, VIR.

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