The right heart in patients with cancer. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology

Kalliopi Keramida¹, Dimitrios Farmakis², Amina Rakisheva³, Carlo Gabriele Tocchetti^{4

5

6

7}, Pietro Ameri^{8

9}, Riccardo Asteggiano^{10

11}, Ana Barac¹², Jeroen Bax¹³, Antoni Bayes-Genis^{14

15

16

17}, Jutta Bergler Klein¹⁷, Chiara Bucciarelli-Ducci¹⁸, Jelena Celutkiene¹⁹, Andrew J S Coats²⁰, Alain Cohen Solal²¹, Susan Dent²², Gerasimos Filippatos², Arjun Ghosh²³, Joerg Hermann²⁴, Yvonne Koop²⁵, Daniel Lenihan²⁶, Teresa Lopez Fernandez^{27

28}, Alexander R Lyon²⁹, Valentina Mercurio^{4

5

6}, Brenda Moura³⁰, Massimo Piepoli^{31

32}, Yusuf Ziya Sener³³, Thomas Suter³⁴, Aaron L Sverdlov^{35

36}, Marijana Tadic³⁷, Thomas Thum^{38

39

40}, Peter van der Meer⁴¹, Sophie van Linthout^{42

43}, Marco Metra⁴⁴, Giuseppe Rosano⁴⁵

Affiliations

¹ Cardiology Department, General Anti-Cancer Oncological Hospital Agios Savvas, Athens, Greece.
² Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School, Athens, Greece.
³ City Cardiological Center, Almaty, Kazakhstan, Qonaev City Hospital, Almaty Region, Almaty, Kazakhstan.
⁴ Department of Translational Medical Sciences (DISMET), 'Federico II' University, Naples, Italy.
⁵ Interdepartmental Center of Clinical and Translational Sciences (CIRCET), 'Federico II' University, Naples, Italy.
⁶ Interdepartmental Hypertension Research Center (CIRIAPA), 'Federico II' University, Naples, Italy.
⁷ Center for Basic and Clinical Immunology Research (CISI), 'Federico II' University, Naples, Italy.
⁸ Department of Internal Medicine, University of Genova, Genoa, Italy.
⁹ IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
¹⁰ Internal Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
¹¹ LARC, Laboratorio Analisi e Ricerca Clinica, Turin, Italy.
¹² MedStar Heart and Vascular Institute, Georgetown University, Washington, DC, USA.
¹³ Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
¹⁴ CIBER Cardiovascular, Madrid, Spain.
¹⁵ Institut del Cor, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
¹⁶ Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
¹⁷ Department of Cardiology, Medical University of Vienna, Vienna, Austria.
¹⁸ Royal Brompton and Harefield Hospital, London, UK.
¹⁹ Centre of Cardiology and Angiology, Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
²⁰ Heart Research Institute, Sydney, NSW, Australia.
²¹ Université Paris Cité, INSERM U-942 MASCOT, Cardiology Department, Lariboisière Hospital, Paris, France.
²² Duke Cancer Institute, Department of Medicine, Duke University, Durham, NC, USA.
²³ Barts Heart Centre, University College London Hospital and Hatter Cardiovascular Institute, London, UK.
²⁴ Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
²⁵ Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
²⁶ Cardio-Oncology Program, St Francis Healthcare, Cape Girardeau, MO, USA.
²⁷ Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, Madrid, Spain.
²⁸ Cardiology Department, Hospital Universitario Quirónsalud Madrid, Madrid, Spain.
²⁹ National Heart and Lung Institute, Imperial College London and Cardio-Oncology Service, Royal Brompton Hospital, London, UK.
³⁰ Armed Forces Hospital, Porto and Faculty of Medicine of the University of Porto, Porto, Portugal.
³¹ Clinical Cardiology, IRCCS Policlinico San Donato, Milan, Italy.
³² Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
³³ Cardiology Department, Beypazarı State Hospital, Ankara, Turkey.
³⁴ Cardiology Department, University of Ulm, Ulm, Germany.
³⁵ Newcastle Centre of Excellence in Cardio-Oncology, The University of Newcastle, Hunter Medical Research Institute, Calvary Mater Newcastle, Hunter New England Health, Newcastle, NSW, Australia.
³⁶ Cardiovascular Department, John Hunter Hospital, New Lambton Heights, NSW, Australia.
³⁷ Klinik für Innere Medizin II, Universitätsklinikum Ulm, Ulm, Germany.
³⁸ Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
³⁹ Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
⁴⁰ Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
⁴¹ Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
⁴² Berlin Institute of Health (BIH) at Charité, BIH Center for Regenerative Therapies, Berlin, Germany.
⁴³ German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany.
⁴⁴ Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
⁴⁵ Cardiology, San Raffaele Cassino, Cassino, Italy.

PMID: 39193837
DOI: 10.1002/ejhf.3412

Free article

The right heart in patients with cancer. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology

Kalliopi Keramida et al. Eur J Heart Fail. 2024 Oct.

Free article

. 2024 Oct;26(10):2077-2093.

doi: 10.1002/ejhf.3412. Epub 2024 Aug 28.

Authors

Affiliations

¹ Cardiology Department, General Anti-Cancer Oncological Hospital Agios Savvas, Athens, Greece.
² Department of Cardiology, Athens University Hospital Attikon, National and Kapodistrian University of Athens Medical School, Athens, Greece.
³ City Cardiological Center, Almaty, Kazakhstan, Qonaev City Hospital, Almaty Region, Almaty, Kazakhstan.
⁴ Department of Translational Medical Sciences (DISMET), 'Federico II' University, Naples, Italy.
⁵ Interdepartmental Center of Clinical and Translational Sciences (CIRCET), 'Federico II' University, Naples, Italy.
⁶ Interdepartmental Hypertension Research Center (CIRIAPA), 'Federico II' University, Naples, Italy.
⁷ Center for Basic and Clinical Immunology Research (CISI), 'Federico II' University, Naples, Italy.
⁸ Department of Internal Medicine, University of Genova, Genoa, Italy.
⁹ IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
¹⁰ Internal Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
¹¹ LARC, Laboratorio Analisi e Ricerca Clinica, Turin, Italy.
¹² MedStar Heart and Vascular Institute, Georgetown University, Washington, DC, USA.
¹³ Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
¹⁴ CIBER Cardiovascular, Madrid, Spain.
¹⁵ Institut del Cor, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
¹⁶ Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
¹⁷ Department of Cardiology, Medical University of Vienna, Vienna, Austria.
¹⁸ Royal Brompton and Harefield Hospital, London, UK.
¹⁹ Centre of Cardiology and Angiology, Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
²⁰ Heart Research Institute, Sydney, NSW, Australia.
²¹ Université Paris Cité, INSERM U-942 MASCOT, Cardiology Department, Lariboisière Hospital, Paris, France.
²² Duke Cancer Institute, Department of Medicine, Duke University, Durham, NC, USA.
²³ Barts Heart Centre, University College London Hospital and Hatter Cardiovascular Institute, London, UK.
²⁴ Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
²⁵ Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
²⁶ Cardio-Oncology Program, St Francis Healthcare, Cape Girardeau, MO, USA.
²⁷ Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, Madrid, Spain.
²⁸ Cardiology Department, Hospital Universitario Quirónsalud Madrid, Madrid, Spain.
²⁹ National Heart and Lung Institute, Imperial College London and Cardio-Oncology Service, Royal Brompton Hospital, London, UK.
³⁰ Armed Forces Hospital, Porto and Faculty of Medicine of the University of Porto, Porto, Portugal.
³¹ Clinical Cardiology, IRCCS Policlinico San Donato, Milan, Italy.
³² Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
³³ Cardiology Department, Beypazarı State Hospital, Ankara, Turkey.
³⁴ Cardiology Department, University of Ulm, Ulm, Germany.
³⁵ Newcastle Centre of Excellence in Cardio-Oncology, The University of Newcastle, Hunter Medical Research Institute, Calvary Mater Newcastle, Hunter New England Health, Newcastle, NSW, Australia.
³⁶ Cardiovascular Department, John Hunter Hospital, New Lambton Heights, NSW, Australia.
³⁷ Klinik für Innere Medizin II, Universitätsklinikum Ulm, Ulm, Germany.
³⁸ Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
³⁹ Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
⁴⁰ Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
⁴¹ Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
⁴² Berlin Institute of Health (BIH) at Charité, BIH Center for Regenerative Therapies, Berlin, Germany.
⁴³ German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany.
⁴⁴ Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
⁴⁵ Cardiology, San Raffaele Cassino, Cassino, Italy.

PMID: 39193837
DOI: 10.1002/ejhf.3412

No abstract available

Keywords: Cancer; Cardiotoxicity; Right ventricle.

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References

1. Herrmann J, Lenihan D, Armenian S, Barac A, Blaes A, Cardinale D, et al. Defining cardiovascular toxicities of cancer therapies: An international Cardio‐Oncology Society (IC‐OS) consensus statement. Eur Heart J 2022;43:280–299. https://doi.org/10.1093/eurheartj/ehab674
1. Lyon AR, López‐Fernández T, Couch LS, Asteggiano R, Aznar MC, Bergler‐Klein J, et al. 2022 ESC Guidelines on cardio‐oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio‐Oncology Society (IC‐OS). Eur Heart J 2022;43:4229–4361. https://doi.org/10.1093/eurheartj/ehac244
1. Christiansen JR, Massey R, Dalen H, Kanellopoulos A, Hamre H, Ruud E, et al. Right ventricular function in long‐term adult survivors of childhood lymphoma and acute lymphoblastic leukaemia. Eur Heart J Cardiovasc Imaging 2016;17:735–741. https://doi.org/10.1093/ehjci/jew018
1. Boerman LM, Maass S, van der Meer P, Gietema JA, Maduro JH, Hummel YM, et al. Long‐term outcome of cardiac function in a population‐based cohort of breast cancer survivors: A cross‐sectional study. Eur J Cancer 2017;81:56–65. https://doi.org/10.1016/j.ejca.2017.05.013
1. Bozkurt B, Coats AJ, Tsutsui H, Abdelhamid M, Adamopoulos S, Albert N, et al. Universal definition and classification of heart failure: A report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail 2021;23:352–380. https://doi.org/10.1002/ejhf.2115

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The right heart in patients with cancer. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology

Affiliations

The right heart in patients with cancer. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology

Authors

Affiliations

References

LinkOut - more resources

Full Text Sources