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Randomized Controlled Trial
. 2024 Aug 26:22:eAO0588.
doi: 10.31744/einstein_journal/2024AO0588. eCollection 2024.

Comparison of the effects of high-flow nasal cannula and bilevel positive airway pressure treatments as respiratory physiotherapy interventions for children with asthma exacerbation: a randomized clinical trial

Maisi Muniz Cabral David  1 , Evelim Leal de Freitas Dantas Gomes  2 , Carla Lima Feitoza Cavassini  1 , Josiane Germano Luiz  1 , Dirceu Costa  1
Affiliations
Randomized Controlled Trial

Comparison of the effects of high-flow nasal cannula and bilevel positive airway pressure treatments as respiratory physiotherapy interventions for children with asthma exacerbation: a randomized clinical trial

Maisi Muniz Cabral David et al. Einstein (Sao Paulo). .

Abstract

Objective: A high-flow nasal cannula is a practical and safe instrument that can be used for children with asthma exacerbation and promotes beneficial outcomes such as improved asthma severity scores and reduced hospitalization durations, salbutamol use, and oxygen use. To evaluate and compare the efficacy of high-flow nasal cannula treatment and that of bilevel positive airway pressure treatment as respiratory physiotherapy interventions for pediatric patients who are hospitalized because of asthma exacerbation.

Methods: During a randomized clinical trial, treatment was performed using a high-flow nasal cannula and bilevel positive airway pressure for hospitalized children with asthma. After randomization, data regarding lung function, vital signs, and severity scores (pulmonary index, pediatric asthma severity, and pediatric asthma scores) were collected.

Results: Fifty patients were included in this study (25 in the Bilevel Group and 25 in the high-flow nasal cannula group). After 45 minutes of therapy, an improvement in the forced expiratory volume in 1 second was observed. The high-flow nasal cannula group required fewer days of oxygen (O2) use, used fewer bronchodilators (number of salbutamol puffs), and required shorter hospitalization periods than the Bilevel Group (6.1±1.9 versus 4.3±1.3 days; 95% confidence interval, -5.0 to -0.6).

Conclusion: A high-flow nasal cannula is a viable option for the treatment of asthma exacerbation because it can reduce the hospitalization period and the need for O2 and bronchodilators. Additionally, it is a safe and comfortable treatment modality that is as effective as bilevel positive airway pressure.ClinicalTrials.gov Identifier: NCT04033666.

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Conflict of interest statement

Conflict of interest:

none.

Figures

None
Graphical abstract
Figure 1
Figure 1. Evaluation sequence
NIV: noninvasive ventilation; HFNC: high-flow nasal cannula.
Figure 2
Figure 2. Patient randomization
Figure 3
Figure 3. Days of oxygen use, days of hospitalization, and the average dose of bronchodilators at discharge
HFNC: high-flow nasal cannula; NIV: noninvasive ventilation.
See this image and copyright information in PMC

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