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. 2024 Aug 26;33(3):e004924.
doi: 10.1590/S1984-29612024044. eCollection 2024.

Albendazole is effective in controlling monogeneans in Colossoma macropomum (Serrasalmidae): therapeutic baths and their physiological and histopathological effects

Raimundo Rosemiro de Jesus Baia  1   2 , Carliane Maria Guimarães Alves  1 , Marcos Sidney Brito de Oliveira  1 , Clara Brito Salomão  3 , Abthyllane Amaral de Carvalho  2 , Marcela Nunes Videira  2 , Eliane Tie Oba Yoshioka  1   3 , Marcos Tavares-Dias  1   3
Affiliations

Albendazole is effective in controlling monogeneans in Colossoma macropomum (Serrasalmidae): therapeutic baths and their physiological and histopathological effects

Raimundo Rosemiro de Jesus Baia et al. Rev Bras Parasitol Vet. .

Abstract
in English, Portuguese

In aquaculture worldwide, most of the chemotherapeutic agents used for disease control and treatment are unregulated chemical products derived from agriculture. In this study, we investigated the efficacy of therapeutic baths with albendazole against the monogeneans Anacanthorus spathulatus, Notozothecium janauachensis and Mymarothecium boegeri, which infest the gills of Colossoma macropomum, and the hematological and histopathological effects of this anthelmintic agent on these fish. Albendazole at a concentration of 500 mg/L was used in three baths of 24 hours each, with intervals of 24 hours between these baths. Three replications of this treatment were used, and the control group consisted of water from the cultivation tank. Afterwards, hematological, histopathological and parasitological analyses were conducted. We found that the therapeutic baths with albendazole at 500 mg/L presented high efficacy (94.9%) against monogeneans de C. macropomum and caused few physiological or histopathological alterations. Therefore, baths with albendazole at 500 mg/L, as used in this strategy, can be recommended for controlling and treating infections by monogeneans in C. macropomum.

Na aquicultura mundial, a maioria dos quimioterápicos utilizados no controle e tratamento de doenças, são produtos químicos não regulamentados e oriundos da agricultura. Neste estudo, foi investigada a eficácia de banhos terapêuticos com albendazol contra monogeneas Anacanthorus spathulatus, Notozothecium janauachensis e Mymarothecium boegeri das brânquias de Colossoma macropomum, e os efeitos hematológicos e histopatológicos causados por esse anti-helmíntico nos peixes. Foram usados 500 mg/L de albendazol e um grupo controle (água do tanque de cultivo) com três banhos de 24 horas, mantendo intervalos de 24 horas entre cada banho, usando três repetições cada. Ao final dos banhos terapêuticos, foram realizadas análises hematológicas, histopatológicas e parasitológicas. Verificou-se que banhos terapêuticos com 500 mg/L de albendazol apresentaram alta eficácia (94,9%) contra monogenéticos de C. macropomum, causando poucas alterações fisiológicas e histopatológicas. Portanto, banhos com 500 mg/L de albendazol, na estratégia usada, podem ser recomendados para controle e tratamento de infecções por monogenéticos em C. macropomum.

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Conflict of interest statement

Conflict of interest :The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1. Histopathology of gills from Colossoma macropomum exposed to albendazole at 500 mg/L and cultivation tank water. (A) Gills of fish exposed to cultivation tank water (control) showing primary (PL) and secondary (SL) lamellae; (B) Aneurism (asterisk*) in the gills of fish exposed to cultivation tank water; (C) Detachment of the lamellar epithelium (arrow) in the gills of fish exposed to cultivation tank water; (D) Total hyperplasia (○) and hyperplasia with partial fusion of the lamellae (+) of fish exposed to cultivation tank water; (E) Aneurysm (*) in the gills of fish exposed to albendazole; (F) Total hyperplasia with fusion of the lamellae (☆) and hyperplasia with partial fusion of the lamellae (+) of fish exposed to albendazole; (G) Detachment of the lamellar epithelium (arrow) and hyperplasia with partial fusion of the lamellae in the gills (+) of fish exposed to albendazole; (H) Gill filament with monogenean (MO) in fish exposed to albendazole.
See this image and copyright information in PMC

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