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Review
. 2024 Jul 26;12(8):236.
doi: 10.3390/dj12080236.

Correlations between Obstructive Sleep Apnea Syndrome and Periodontitis: A Systematic Review and Meta-Analysis

Marco Portelli  1 , Ignazio Russo  1 , Angela Mirea Bellocchio  1 , Angela Militi  1 , Riccardo Nucera  1
Affiliations
Review

Correlations between Obstructive Sleep Apnea Syndrome and Periodontitis: A Systematic Review and Meta-Analysis

Marco Portelli et al. Dent J (Basel). .

Abstract

The focus of this article was to evaluate the link between obstructive sleep apnea syndrome (OSAS) and periodontitis, considering various hypotheses supporting the relationship between respiratory disorders and periodontitis. The literature review for this study was performed using the PubMed, Google Scholar, Cochrane library, and Proquest databases. The review process was guided by the PRISMA guidelines. The PECOS protocol (Population, Exposure, Control, Outcome, Study) was followed in developing the search strategy to ensure consistent and accurate selection of articles. To evaluate quality, cross-sectional studies were reviewed using the Joanna Briggs Institute (JBI) critical appraisal tool. Case-control studies were assessed with the Newcastle-Ottawa Scale (NOS). The research included a total of 10 studies, encompassing 88,040 participants. The meta-analysis observed a statistically significant association between OSAS and periodontitis, with an odds ratio OR = 2.4620 (95%-CI: 1.7345-3.4946 p ≤ 0.0001). The results suggest a potential association between OSA and periodontitis. Further investigations are warranted to confirm this association and elucidate its underlying mechanism.

Keywords: OSAS; inflammation; oxidative stress; periodontitis; xerostomia.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of study selection performed according tot PRISMA guidelines.
Figure 2
Figure 2
Forest plot of the association between OSAS and periodontitis [18,19,25,26,27,28,29,30,31,32].
See this image and copyright information in PMC

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